The Status Of Vitamin D And Inflammatory Factors In Pneumoconiosis Patients Of Suzhou

Objective: The aim of this study is to investigate the status of vitamin D and inflammatory factors in pneumoconiosis patients of Suzhou, to analyze the effect of vitamin D levels on the relative indexes of pneumoconiosis patients, and the correlation between vitamin D and related indexes.Methods: Pneumoconiosis patients hospitalized in the Fifth People’s Hospital of Suzhou from 2013 August to 2014 November were recruited in this study. Levels of 25 hydroxy vitamin D(25(OH) D), calcium(Ca), phosphorus(P), alkaline phosphatase(ALP)and interleukin 2 receptor(IL-2R), interleukin 6(IL-6), interleukin 8(IL-8), interleukin 10(IL-10), tumor necrosis factor alpha(TNF-α), calcitonin peptide(PCT), white blood cell count(WBC) and high sensitive C reactive protein(CRP) in serum were determined. The effects of vitamin D levels on Ca, P, ALP, IL-2R, IL-6, IL-8, IL-10, TNF-α, PCT, WBC and CRP of pneumoconiosis patients and the correlation between vitamin D and above indicated indexes were analyzed.Results: The present study contents 125 pneumoconiosis patients, the main results were as follows:(1) The average concentration of 25(OH)D in pneumoconiosis patients serum was28.01±6.45ng/ml. 55.2% of pneumoconiosis patients were vitamin D deficiency(<30ng/ml), and 44.8% of pneumoconiosis patients were 25(OH)D sufficient(>30ng/ml).(2) The season seriously affected serum 25(OH) D levels of pneumoconiosis patients.The concentrations of 25(OH)D were highest in winter, and was gradually decrease in summer and autumn, and exhibited the lowest level in spring. There was no difference of serum 25(OH) D levels between different genders, ages and stages of silicosis.(3) Vitamin D have no effects on the levels of Ca, P, ALP, IL-2R, IL-6, IL-8, IL-10,TNF-α, PCT, WBC and CRP in pneumoconiosis patients.(4) The serum level of 25(OH) D in patients with pneumoconiosis was only correlated with phosphorus, and there was no correlation with other indexes. Significantnegative correlations were observed between levels of 25(OH)D and phosphorus(r =-0.21, P= 0.02) in pneumoconiosis patients serum.Conclusions:(1) Vitamin D level in pneumoconiosis was significantly decrease, and also had an obvious seasonal difference, which exhibited the lowest level in spring. These results suggested that sufficient vitamin D should be supplement to pneumoconiosis patients.(2) Further study should be carried out to clarify the long-term health effects of vitamin D and the relationship between vitamin D and inflammatory factors in pneumoconiosis.(3) The baseline level of vitamin D was measured in pneumoconiosis. Our study would provided a solid foundation for long-term health effects study of vitamin D deficiency and the establishment of cohort study in the future.