Analysis Of Risk Factors Of Pneumoconiosis Patients Complicated With Pulmonary Infection

Background: Epidemiological survey on patients with pneumoconiosis in China showed that,the respiratory system complications accounted for the first place,51.8%,which is mainly pulmonary infectious diseases,tuberculosis and pneunothorax.In particular,lung infection has become an important cause of the deterioration of pneumoconiosis patients,increased mortality and medical costs.At the same time,combined with pulmonary infectionin patients with pneumoconiosis long time to cure,prone to repeated infection,poor prognosis,and even lead to death.Therefore,early correct diagnosis and treatment of various complications,is to rescue the lives of patients,improve the prognosis,an important measurement of improve the quality of life of the patients.But there is little evidence of the associated risk factors for such pneumoconiosis patients with pulmonary infection Objective:Tostudy the relationship betweenthe Pneumoconiosis complicated andpulmonary infection in patients by analyzing the clinical information,the onset season,the age of dust,the stage of pneumoconiosis,lung function impairment and mortality indicators,related risk factors on the predictive value of patients with pneumoconiosis complicated with pulmonary infection.Especially pneumonia,pneumoconiosis disease progression and mortality increased and an important cause of increase in medical costs.Method: 1.In this study,selected 285 cases of pneumoconiosis patients were hospitalized from June 1,2015 to May 31,2016 in our hospital randomly.According to whether the merger of lung infection,divided into two groups: Group A: without pulmonary infection in188cases(179 of male,95.2%).Group B: was 97 cases with pulmonary infection(85 males and 87.6%of men).2.Retrospective clinical data collection of all hospitalized patients in General,including the patient's age,sex,smoking history,hypertension,diabetes and so on.The levels of white blood cell count,neutrophil ratio,total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,urea nitrogen,creatinine,uric acid,C-reactive protein,T cell-CD4,Tcell-CD8 and so on were also detected index.Collection of patients admitted to hospital when the onset of the season,the dust years,pneumoconiosis stage,type of lung damage,whether the death during hospitalization.3.Relevant information on comparison between the two groups,and analysis the relevant factorson patients with pneumoconiosis complicated with pulmonary infection.4.Multivariate logistic regression analysis was used to assess the predictive value of the associated variables in pneumoconiosis patients with pulmonary infection.Results: 1.The age,proportion of smokers,white blood cell count,neutrophil ratio,CRP and HDL-C were significantly higher in pneumoconiosis group than in those without lung infection.The differences were statistically significant.2.The proportion of Tcell CD4,the proportion of male patients,uric acid and high blood pressure in the pneumoconiosis group was significantly lower than that in the pneumoconiosis group without pulmonary infection.The differences were statistically significant.3.The age of dust in the pneumoconiosis group was significantly higher than that in the non-pulmonary infection group,the difference was statistically significant.4.The incidence of restrictive ventilation disorder in the pneumoconiosis group was significantly lower than that in the non-pulmonary infection group(P <0.05).The difference was statistically significant.The incidence of mixed ventilatory disorder in the pneumoconiosis group was significantly higher than that in the non-pulmonary infection group(P <0.05).The difference was statistically significant.There was no significant difference in the incidence of obstructive ventilatory disorder between the pneumoconiosis group and the non-pulmonary infection group.5.The elevated CRP is an independent predictor of pulmonary infection in patients with pneumoconiosis.6.Season is an independent predictor of pneumoconiosis with pulmonary infection.Combined lung infection in the pneumoconiosis group occurred more in the first quarter,no lung infection pneumoconiosis group occur mostin the 2nd quarter,two sets of seasonal distribution of pulmonary infection was statistically significantly.Compared with the first quarter,2nd quarter of pneumoconiosis complicated with pulmonary infection risk is decreased,the difference was statistically significant;Compared with the 3 quarter,the risk of pulmonary infection in patients with pneumoconiosis increased in the 4 quarter,the difference was statistically significant.compared with the 2 quarter,there was no significant difference in the risk of pulmonary infection in the 3 quarter.7.Pneumoconiosis stage is an independent predictor of pneumoconiosis patients complicated with pulmonary infection.Combined with pulmonary infection pneumoconiosis group is more stage II,stage III pneumoconiosis patients,no lung infection pneumoconiosis group is more stage I pneumoconiosis patients,the difference between the two groups was statistically significant.The risk of pulmonary infection in stage ? pneumoconiosis patients was higher than that in pneumoconiosis patients,and the difference was statistically significant.There was no significant difference in the risk of pulmonary infection between stage ? and stage ? pneumoconiosis patients.8.The mortality rate of pneumoconiosis group was significantly higher than that of the group without lung infection,the difference was statistically significant.Conclusion: 1.Pneumoconiosis patients with lung infection were older,longer dust exposure,and higher proportion of smokers.2.White blood cell count,neutrophil ratio,CRP,HDL-C were significantly increased in patients with pneumoconiosis complicated with lung infection.3.Patients with pneumoconiosis complicated with pulmonary infection occurred more frequently in the 1 and 4 quarters of the year,and had a higher prevalence of mixed ventilatory disorders;Pneumoconiosis in pulmonary infection-free of restrictive ventilation disorder group higher.4.Compared with pneumoconiosis patients,the risk of pulmonary infection was significantly higher in pneumoconiosis patients.5.The mortality rate in the pneumoconiosis group was significantly higher than that in the combined lung infection group.6.Season,CRP increased and pneumoconiosis stage were independent predictors of the pneumoconiosis patients complicated with pulmonary infection.