Meta-analysis And Clinical Observation Of Effect Of Dezocine For Gastroscopy

Objective: 1. By using the method of meta analysis system evaluation of dezocine combined with propofol for clinical efficacy and safety of electronic gastroscopy. 2. We clinical observates and contrasts dezocine united propofol for safety, effectiveness and superiority of gastroscopy.Methods:Part 1: We collected randomized controlled trials(RCTs) about dezocine combined with propofol on electronic gastroscopy by carrying out a meta-analysis based on data by searching Pubmed,CNKI,Wanfang and VIP databases from the establishment of the databases to December 2015.Meta analysis was performed by using Review Manager 5.3 software.The evaluation indicators included the total dosage of propofol, recovery time, body dynamic response, respiratory depression, postoperative VAS score, basic vital signs, the occurrence of nausea and vomiting.Part 2: A total of 38 patients(ASAⅠorⅡ) who underwent gastroscopy were randomly divided into two groups,:group D(dezocine + propofol)and group P(propofol), n=19.Group D was injected dezocine 0.03 mg/kg intravenously, five minutes later two groups were injected with propofol of 1.5-2.5 mg/kg to patients into deep sleep. surgery were performed by an experienced doctor. The total dosage of propofol, recovery time, body dynamic response, respiratory depression, postoperative VAS score, basic vital signs, the occurrence of nausea and vomiting were observed.Results:Part 1: Nineteen randomized controlled trials with 2253 patients were included. There were 1127 patients in the dezocine-propofol group and 1126 patients in the propofol group.The Meta-Analysis by RevMan 5.3 showed that compared with propofol group,the total dosage of propofol significantly reduced in combination group(MD=-34.59, 95%CI[-42.49,-26.69],P<0.01),the recovery time was shortened(MD=-1.61, 95%CI[-2.08,-1.14],P<0.01),the body dynamic response(RR=0.27, 95 %CI[0.18,0.42], P<0.01) and the incidence 0f respiratory depression(RR=0.43, 95 % CI[0.31,0.60], P<0.01)reduced,the dropping of blood pressure(MD=9.46, 95%CI[7.64,11.27],P<0.01) and the decrease of Sp O2(MD=2.38, 95%CI[1.11,3.65],P<0.01)and onther risk of circulation inhibition decreased.And there was no significant difference between the two groups in VAS score(MD=-1.35,95%CI[-3.07,0.37],P=0.12) and the occurrence ofpostoperative nausea and vomiting(MD=0.8,95%CI[0.55,1.18], P=0.26).Part 2: It reflected a statistical difference in the dosage of propofol and recovery time between the two groups(P < 0.05). The two groups after anesthesia MAP and HR were lower than before operation(P < 0.05),the dropping of MAP is more obvious in the D group(P < 0.05). The body dynamic response of Group D is decreased significantly compared with group P(P < 0.05). There was no significant difference between two groups in respiratory depression and postoperative nausea and vomiting(P > 0.05).Conclusion: Dezocine combined with propofol for electronic gastroscopy is safe and effective.