Comparison Of Anesthesia Effect Of Oxycodone And Dezocine Combined With Target-controlled Infusion Of Propofol In ERCP

Objective:This study is designed to evaluate the c linical effect of oxycodone and dezocine combined with target-controlled infusion of propofol in endoscopic retrograde cholangiopancreatography（ERCP）.Methods:Fifty patients undergoing ERCP under intravenous genera l anesthesia were inc luded and randomly divided into oxycodone group（n=25）and dezocine group（n=25）.The oxycodone group was induced by intravenous infus ion of oxycodone 0.1 mg/kg combined with propofol TCI,and propofol TCI was maintained during the operation.The dezocine group was induced by intravenous infusion of dezocine 0.1mg/kg combined with propofol TCI,and propofol TCI was maintained during the operation.The mean arterial pressure（MAP）,SPO₂ and HR of the two groups of patients were recorded at the time of entering the room（T0）,5 minutes after intravenous analges ia（T1）,when the endoscope entered the throat（T2）,and when the endoscope entered the opening of the duodenal papilla（T3）;recorded operation time and patient recovery time;recorded the inc idence of anesthesia-related adverse events such as intraoperative severe hypotension,respiratory depression,body movement,postoperative agitation,nausea and vomiting.Results:The probability of anesthes ia-related adverse reactions in the dezocine group was significantly higher than that in the oxycodone group（P<0.05）;the postoperative recovery time in the dezocine group was significantly longer than that in the oxycodone group（P<0.05）;the T5time point in the oxycodone group SPO₂ was significantly higher than dezocine group（P<0.05）;there was no significant difference in MAP levels between the two groups at each time point（P>0.05）;SPO₂ levels at T0,T1,T2,T3,and T4 in the two groups There was no significant difference（P>0.05）;there was no significant difference in HR levels between the two groups at each time point（P>0.05）.Conclusions:Both oxycodone and dezocine can meet the anesthesia requirements of ERCP and are hemodynamically stable.However,compared with dezocine,oxycodone provides faster postoperative recovery,less intraoperative and postoperative adverse reactions,high safety,and is suitable for clinical anesthesia applications in ERCP surgery.