A Clinical Research On Drug-Thread Embedding Treatment Of Colonic Slow Transit Constipation

Research objectives: Observing a clinical research on drug-thread embedding treatment of colonic slow transit constipation.Methodology: 92 patients suffering from colonic slow transit constipation had been randomly divided into 3 groups including a drug-thread embedding group, a catgut comparison group, and a Mosapride Citrate orally-taken group. The drug-thread embedding group involved 31 patients; the catgut comparison group involved 30 patients; and the Mosapride Citrate orally-taken group involved 29 patients. Patients in drug-thread embedding group and catgut comparison group were treated once, and the patinets in Mosapride Citrate orally-taken group took medicine for 2 weeks. Symptom scores and total effectivity rate were observed in the second, fourth and sixth week before the treatment.Results:1.In the second week, patients in all three groups were relatively improved. The total effectivity rate of drug-tread embedding was 96.8%; the total rate of catgut comparison group was 90.0%; and the total effectivity rate of Mosapride Citrate orally-taken group was 86.2%. P>0.05 suggested little statistical meaning. The difference of efficacy among patients in three groups are hardly obvious in the second week.2.In the fourth week, the total effectivity rate of drug-tread embedding group was96.8%, the total rate of catgut comparison group was 90.0%;and the total rate of Mosapride Citrate orally-taken group after 2 weeks’ drug suspend was 37.9%. Comparing drug-tread embedding group with catgut comparison group resulted in P>0.05, which carried little statistical meaning. However, comparing Mosapride Citrate orally-taken group with both drug-tread embedding group and catgut comparison group individually resulted in P<0.01, which was meaningful in statistic.It was indicated that in the fourth week, the efficacy of drug-thread embedding and catgut varied little, while totally they had obviously better total effectivity rate than the Mosapride Citrate orally-taken group.3. In the sixth week, the total effectivity rate of drug-tread embedding group was 96.8%,the total rate of catgut comparison group was 90.0%;and the total rate of Mosapride Citrate orally-taken group after 6 weeks’ drug suspend was 27.6%. Comparing drug-tread embedding group with catgut comparison group, P>0.05; and comparing Mosapride Citrate orally-taken group with both drug-tread embedding group and catgut comparison group individually, P<0.01. So It was indicated that in the sixth week, the efficacy of drug-thread embedding and catgut varied little, while totally they had obviously better total effectivity rate than the comparing Mosapride Citrate orally-taken group.4. About symptom scores in improving defecation strength-taken and defecation time improvement, the groups of catgut and Mosapride Citrate orally-taken are compared with drug-tread embedding group individually in the second, fourth, sixth week and all resulted in P<0.05 which was meaningful in statistic, suggesting that drug-tread embedding method provided better improvements than catgut and Mosapride Citrate orally-taken comparison group on defecation strength-taken and defecation time. As for residual symptoms, in the second, fourth and sixth week, they were generally P>0.05, suggesting little statistical meaning.Conclusion: Drug-tread embedding method stood out in the treatment of colonic slow transit constipation. Its long-term effect almost equaled that of catgut comparison group while it overmatched orally-taken medicine obviously. And it overmatched catgut comparison group in improving defecation strength-taken and defecation time.