Effect Of Sarcopenia On Bone Mineral Density And Health-Related Quality Of Life In Men

Background:Sarcopenia is a common clinical degenerative disorder in older people. The characteristic manifestation is the decrease in muscle volume, muscle strength and number of muscle fibers and functional impairment following the aging. Sarcopenia is the main cause of old people falling. What’s more, falling is an important risk factor of Osteoporotic Fracture (OF). Studies show that there are various dangerous risk factors in sarcopenia and osteoporosis. The relationship between sarcopenia and osteoporosis has been studied. However, the results are inconsistent. The aim of this study is to evaluate the effect of sarcopenia on bone mineral density (BMD) and the quality of life.Objective:To evaluate the the effect of sarcopenia on bone mineral density and the quality of life. To provide clinical information theoretical basis for preventing and treating osteoporosis.Methods:A total of 177 over 50 years old men who are retired workers and healthy physical examination people were investigated in this study from Qilu Hospital of Shandong University. All of them signed the Informed Consent Paper before participating in the study. The bone mineral density, T value and the whole body composition are detected by Dual energy X-ray absorptiometry (DXA).The instrument used to measure the quality of life is EuroQol (EQ-5D). Diagnostic criteria for osteoporosis is taken WHO recommended diagnostic criteria which is based on the DXA. The criteria for sarcopenia is followed by the standard of Asia Working Group for Sarcopenia (AWGS), based on the determination of DXA, with RSMI= ASMM/height2 (kg/m2), RSMI 7.0 kg/m2 or less for male. And there are 42 patients in sarcopenia group. The others are non-sarcopenia group. Then we evaluate the association between bone mineral density, lifestyle and its effect on the quality of life in sarcopenia group and non-sarcopenia group. All data is processed by SPSS 22.0 software. Statistical methods included paired samples t test, nonparametric rank sum test, Pearson correlation, Spearman correlation and chi-square test. P<0.05 was considered statistically significant.Results:1、Sarcopenia detection rate in this study is 23.74%; The detection rate of osteoporosis is 18.64%; and the detection rate of osteopenia is 39.55%. The detection rate of sarcopenia is increasing with age. The detection rate of older men more than 80 years old is as high as 58.33%.2、The average weight, BMI, AFM and BMD of lumber and femur neck in sarcopenia group is lower than it in non-sarcopenia group. SMI and age have negative correlation and there is positive correlation between SMI with BMI, AFM, lumbar and femoral neck BMD. Under the condition of age, height, weight, BMI for control variables, SMI and femoral neck BMD are positively correlated, but negative correlation with AFM.3、The effects of sarcopenia on patients’life quality:The EQ-5D index in sarcopenia group is lower than non-sarcopenia group. However, there is no statistically significant. Both the patients in the two groups have more and obviously problems in the fourth one, that is pain/discomfort. About 50% people in SP group have problem in this aspect. About 60.74% people in NSP group have problem in this aspect.Conclusion:1、Sarcopenia patients who are older than 50 years old men have a high risk of osteoporosis.2、As for quality of life, sarcopenia patients are lower than non-sarcopenia patients but there is no significant difference. We should carry out sarcopenia patients’ psychological counseling and drug intervention as soon as possible.