| Background. Gastric cancer is one of the most common malignancies worldwide, and its incidence in China alone accounts for nearly half of all cases around the world. Most cases of gastric cancer in China are diagnosed as advanced gastric cancer.. Years of clinical practice has proven that the efficiency of advanced gastric cancer is not positively associated with the unlimited expansion of operation range, while comprehensive treatment mainly based on surgery is a major way to further improve its efficiency. We applied preoperative chemotherapy via intra-arterial and intravenous administration to treat unresectable locally advanced gastric cancer. The study is to determine the influence of chemotherapy on T lymphocyte subsets.Methods.105 patients with unresectable locally advanced gastric cancer (Stage ⅢB and ⅢC) were selected for preoperative chemotherapy with FLEEOX regimen.5-Fu (370 mg/m2) and leucovorin (200 mg/m2) were administered by intravenous infusion on day 1-5. Intra-arterial administration of etoposide (80 mg/m2), oxaliplatin (80 mg/m2) and epirubicin (30mg/m2) was performed by Seldinger method on day 6 and 20, repeated 2 cycles. Contrast-enhanced CT and T-lymphocyte antigen (CD3+、 CD4+CD3+、CD8+CD3+、CD4+/CD8+) in peripheral venous blood were reviewed.Results. The response rate of preoperative chemotherapy was 78.1%(82 of 105 patients), with 7 cases of CR and 75 cases of PR, respectively. Before chemotherapy, the percentage of CD3+ T-lymphocyte, CD4+CD3+ T-lymphocyte and CD8+CD3+ T-lymphocyte and the ratio of CD4+/CD8+in those patients showed no statistical significance (P>0.05). After chemotherapy, the percentage and number of the CD3+、CD4+CD3+、CD8+CD3+T cells and CD4+/CD8+ ratio increased significantly in the group that responded (P<0.05).Conclusions. The immune function of patients with Stage ⅢB and ⅢC gastric cancer showed no obvious difference. The preoperative chemotherapy via intra-arterial and intravenous administration could reverse tumor immune suppression. |
PDF Full Text Request