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Astragalus Injection Joint Pf Regimen Of Chemotherapy In Advanced Gastric Cancer Preoperative Clinical Efficacy Observed

Posted on:2007-10-18Degree:MasterType:Thesis
Country:ChinaCandidate:J ZhangFull Text:PDF
GTID:2204360185992170Subject:Traditional surgery
Abstract/Summary:PDF Full Text Request
Investigation Background: Gastric cancer is one of malignant tumors severely threatened Chinese people's health, It has a high incidence and is the most high in gastrointestinal tumors. In china, the mortality of gastric cancer ranks first among other cancers.But in fact when many patients are seeking medical advice, their illness has reached an middle-advanced stage. Because of wider focal infiltration and lower immunologic function, radical operation can not be taken successfully . Followed by the new-adjuvant chemotherapy to bing up,a new way of comprehensive preoperative treatment before operation has been developed for gastric cancer in high advanced stage .For to confer the effect of chinesemedicine in this territory, we choose Huangqi adjection . to treat patients with advanced gastric (cardia) cancer before operation and do some clinical discussion .Methords: To collect 24palients of advanced gastric (cardia) cancer.theexperimental group is 9cases and the contrast group is 15cases(2proups).Bestow Huangqi adjection to the control proup patients ,80ml/d,ivggt×7d,combined with low dose PF plan(DDP + 5-Fu)by continuous intravenous drip as neo-adjuvant chemotherapy.To contrast the proup only with chemotherapy and thegroup treated with aidi injection . The other therapeutic medicine is similar in three proups . observe cancer cell apoptosis index(AI), plasma Soluble Interleukin-2 Receptor(sIL-2R) Levels when it's the 14th day after operation, and observe the patients'unpleasurement when they are having chemotherapy.Ruselts: statistical analysis indicates that:compared with the chemotherapy group the level of AI of the experimental group after operation has a great increase(P< 0.05) . and the plasma Soluble Interleukin-2 Receptor(sIL-2R) Levels has great decrease(P < 0.05) .when compared with Aidi group doesnot has any statistics vaule(P>0.05) .when in the course of chemotherapy , the unpleasurement of Huangqi group has a great decrease comparing with the chemotherapy group(P<0.05) . Thus it can be seen that before operation using Huangqi injection by intravenous drip with PF plan to treat patients with advanced gastric cancer can enhance apoptosis of cancer...
Keywords/Search Tags:neo-adjuvant chemotherapy, advanced gastric cancer, Huangqi injection, cell apoptosis, immunologic function
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