The Study On Metamemory Monitoring In Patients With Idiopathic Generalized Epilepsy

Objective Idiopathic generalized epilepsy is generalized seizure type, with a va riety of cognitive impairment, but there is no research of metamemory monitorin g behavioral research. Memory monitoring is an advanced cognitive function of t he brain, and feeling-of-knowing is the classical classic paradigm. The aim of thi s paper is to investigate the ability of metamemory monitoring in patients with i diopathic generalized epilepsy(IGE) and explore the possible mechanism of the memory impairment.Methods We choice 31 patients who was diagnosed IGE in the First Affiliate d Hospital of Anhui Medical University, Department of Neurology, Epilepsy Cli nic and 30 healthy control participants to test their feeling-of-knowing. The feeli ng-of-knowing(FOK) paradigm of episodic memory(EM) and semantic memory(SM) were established and subsequently administered in 31 IGE patients and 30 healthy control(HC) participants who were matched in age、sexuality and educ ational level.Results Compared with healthy control group( feeling-of-knowing of episodic memory(FOK-EM) FOK accuracy 85.29%±16.84%; feeling-of-knowing of se matic memory(FOK-SM) recall(76.61%±18.66%), the FOK-EM FOK accuracy(64.03%±22.10%) and FOK-SM recall(53.27%±26.91%) in IGE patients were significantly impaired( t=-4.215, p<0.01; t=-3.677,p<0.01). The correct jud gment and correct recognition of FOK-EM(51.16%±32.93%) and the false judgment and correct recognition(21.07%±24.38%) of FOK-EM in the IGE group were significantly different with the HC group(the correct judgment and corre ct recognition of FOK-EM: 79.34%±27.26% and the false judgment and correct recognition of FOK-EM: 2.45%±5.38%; t=-3.634,p<0.01; t= 4.149,p<0.01). Most importantly, the false judgment and correct recognition of FOK-EM were correlated with the Digital Span Test, Vocabulary Fluency Test and the Str oop effect in IGE group(r=-0.309,p<0.01; r=-0.355,p<0.01; r=-0.354,p<0.01; r= 0.602,p<0.01).Conclusions Our results show that the IGE group made less accurate metamemory monitoring than the HC group by underestimating their memory performance on FOK-EM, whereas the semantic metamemory monitoring was not impaired in IGE group. More importantly, the impairment of memory monitoring was correlated with the deficit of executive function, indicating that this mechanism could be an influential factor of memory disorder in IGE. It’s also indicates the episodic and semantic metamemory monitoring depending on different neural network.