Aassocitaion Analysis Of EIF4G1 And Parkinson’s Disease In Xinjiang Uygur And Han Nationality

Objective: TO determine the association between EIF4G1 and Xinjiang Uygur and Han people with Parkinson’s disease(PD). To determine the known mutation P.R1205 H and P.A502 V are the pathogenic factor of PD in Xinjiang Uygur and Han people. Chosing the genetic polymorphism’s site to analysis the association between it and Xinjiang Uygur and Han people with Parkinson’s disease(PD). Method: A case-control study with polymerase chain reaction—restriction fragment length polymorphism(PCR·RFLP) method was performed on 150 cases of PD and 130 age,sex,and national-matched healthy controls for rs200221361 polymorphism analysis and Sanger. Results: Speccific mutation were chosen for further seqencing in a case-control study including 150 sporadic PD and 130 healthy contols. Then, Finding the three variants to locate the 10 exonic, the rs200221361 is non-synonymous variants. The frequencies of rs200221361 genotype and allele between PD and control groups in Uygur and Han people showed no significant difference(for genotype,2? =0.186,P>0.05;for allele,2? =0.063,P>0.05).Sratified analysis showed that no differences in allele and gen- otype frequencies of rs200221361 genotype between PD and control groups among the age,gender or race(P>0.05) Conclusion: 1. Our data suggest that P.Ala502 Val and P.Arg1205 H may not be a pathogenic mutation to PD in Xinjiang Uygur and Han people. 2. The polymorphism of the rs200221361 may have nothing to do with the oceurrence of PD in Uygur and Han people of Xinjiang.