Influence Of CYP3A4*1G And COMT Val158met Gene Polymorphism On Analgesic Effect Of Fentanyl After Patients Of Xinjiang Uygur And Han Nationality

Objective: To study the distribution characteristics of polymorphism of CYP3A4*1G and COMTval158 met in Uygur and Han nationality population, and their relationships with postoperative dosage of fentanyl and the analgesia effects. Methods: 80 patients with gynecological surgery under general anesthesia were selected, who were at grade I or II according to American Society of Anesthesiologists(ASA). The patients were divided into two groups based on nationality: the Uighur nationality group(n=40) and the Han nationality group(n=40). Polymerase chain reaction- restriction fragment length polymorphism(PCR- RFLP) was adopted to detect the polymorphism of CYP3A4*1G and COMTval158 met. Patient controlled intravenous analgesia(PCIA) with fentanyl was adopted. And the visual analogue scale(VAS), Ramasay sedation scores and vital signs at postoperative 6, 24 and 48 h and total amount of fentanyl within postoperative 48 h for PCIA were compared. Results: 1.There were statistically significant differences between the two groups in distribution of 3 genotypes of CYP3A4*1G and COMTval158 met. 2. There were no statistically significant differences between two groups of patients in pulse oxygen saturation(Sp02), Ramasay scores and VAS scores at each time point(P >0.05). 3. Total amount of fentanyl within 48 h of PCIA in group Uygur Nationality Patients was significantly greater than that of group Han Nationality Patients(P < 0.05). Conclusion:There are ethnic differences between Uygur and Han nationality in polymorphism of CYP3A4*1G and COMTval158 met, which may be the main factor that causes differences between nationalities in postoperative analgesic effects of fentanyl.