| Background and objective: Ovarian cancer(OC) is one of the highest vulnerability malignancy among female reproductive system worldwide, It is a leading cause of death from gynecologic malignancies and the fifth leading cause of all gynecologic disease death with an estimated 200,000 incident cases and 150,000 deaths annually. Type of epithelial ovarian cancer(EOC) accounts for 90% of total ovarian cancer. Although today’s world science and technology, medicine highly developed, but still can not change the high incidence of ovarian cancer, the status quo of high mortality. Early-stage EOC, however, is associated with a good prognosis; the indicated 5-year survival for patients with surgically evaluated stage I disease is approximately 60-90%. And the patient with advanced-stage(International Federation of Gynecology and Obstetrics [FIGO] III/IV) EOC, though after active treatment(consists of primary debulking surgery, followed by adjuvant chemotherapy), is still nearly 80% of patients without control there are still nearly 80% of the patients with disease progression. Therefore, now better understand the clinical characteristics of ovarian cancer, to improve the early diagnostic rate become a problem to be solved. Traditional FIGO staging and clinical staging of forward play an important role in clinical work. And the dualism model gradually recognized by people in recent years. Some scholars think the dualist can type in epithelial ovarian cancer early diagnosis and individualized treatment play a key role. Therefore, based on the theory of dualism of the model, by means of type I and type II epithelial ovarian cancer patients with clinical pathological features were retrospectively analyzed, aimed at exploring the dualism of ovarian cancer model significance and application value in clinical diagnosis and treatment work.Materials and methods 1.Research materials: Select from January 2012 to July 2015 in the initial treatment of patients with Jilin University Bethune First Hospital gynecology clinic for the study cases. According to dualism model theory to classify in type I ovarian cancer patients with a total of 83 cases. According to the FIGO clinical stage : 23 cases of stage I,26 cases of stage II,26 cases of stage III and 8 cases of stage IV. Their average age is 50±14.There are 143 cases of type II ovarian cancer including 8 cases of stage I,24 cases of stage II,98 cases of stage III and 13 cases of stage IV. Their average age is 54±9.All the patients who was chose in our study were first onset. and had not received preoperative radiotherapy, chemotherapy, immunotherapy and other treatments They all underwent surgery treatment, and their pathological type were confirmed in postoperative pathology. Out at the same time with other system in patients with severe disease. 2.Research methods: By retrieving the archive records. We collect two groups of patients duration, menstrual history, lesion, lesion size, tumor marker levels before surgery, preoperative examination and treatment, surgery, the chemotherapy, FIGO clinical stage and pathological degree of differentiation of clinical data. Based on clinical data of two groups of patients were analyzed to investigate the clinical and pathological characteristics of type I and type II EOC dualism model and its clinical significance. 3. Statistical method Applications SPSS19 0 software for statistical analysis, measurement data to X ±S, between the two groups were compared using a t-test or t ’test; among groups were compared using one-way analysis of variance was used to compare the rate of count data chi-square test or Fisher’s exact test, the factors that may affect the application binary logistic regression analysis, P <0.05 was considered statisticallysignificant. Results: Type I ovarian cancer patients mean age(50 ± 14) years old was significantly less than II ovarian cancer group(54 ± 9)(P = 0.005), menopause rate at onset of type I ovarian cancer group also less than II ovarian cancer group( 45.85% vs 60.8%, P = 0.028), the preoperative clinical examination of patients with ascites higher type ⅱ Imaging detection rate(72%), preoperative serum CA125 and HE4 levels higher than the type I(P all less than 0.001); high I ovarian cancer surgery resection rate of patient satisfaction and complete resection rate than ⅱ stage ovarian cancer group, but poor sensitivity to chemotherapy(57.8% vs 72%). The other two groups of patients with ascites differences were statistically significant(P values were 0.01).Conclusion 1. Dualistic model of type I and type II ovarian cancer ovarian cancer there are some differences in clinical characteristics. 2. HE4 level helps detect CA125 ovarian cancer diagnosis, and have a role in the differential I and II ovarian cancer. 3. Dualism model theory of ovarian cancer may guide individualized treatment and early diagnosis of ovarian cancer. |
