An Analysis On Clinical Value Of "Dualism Model" For Epithelial Ovarian Carcinoma

Objective:To analyze the clinical-pathological characteristics of two types of epithelial ovarian carcinoma (EOC) and the value in clinical application of the "dualist model".Methods: Totally160patients with primary epithelial ovarian carcinoma were analyzed retrospectively. All cases were divided into type Ⅰ and type Ⅱ EOC according to a "dualism model". The clinical and pathological characteristics, response to chemotherapy, and the prognosis in two types of EOC were analyzed and compared。Results:The mean age of type I EOC was48years, younger than that of type Ⅱ (52years). type Ⅰ EOC were in early stage(FIGO Ⅰ-Ⅱ), which was significant higher than that of type Ⅱ (χ2=17.259, p=0.000). The tumor size of type Ⅰ EOC was bigger than that of type Ⅱ(χ2=5.826, P=0.016). Amount of preoperative ascites in type Ⅰ EOC was less than that of type Ⅱ (χ2=5.621, P=0.018). Ratio of cases with residual tumor size <2cm after primary surgery in type I EOC was89.9%, higher than that in type Ⅱ (73.6%,χ2=7.236, p=0.007). Type I EOC had less abnormal CA125(χ2=13.694, P=0.000) and lower CA125levels(χ2=17.378, P=0.000) compared with type Ⅱ. CA125level of type I EOC more easily descended to normal after three courses of chemotherapy (χ2=4.492, P=0.034).The3-year overall survival rate was88.2%and mean overall survival time was80.4in type I EOC patients, which was significant higher than those in type Ⅱ (χ2=11.617, P=0.001), which was much higher than type Ⅱ EOC.The3-year progression-free survival rate was84.5%, and mean progression-free survival time was79.8month in type I EOC,which was much higher than the high grade serous carcinoma (χ2=10.905, P=0.001)Conclusion:Compared with type II EOC, there were younger age, more early stage, bigger tumor size, less amount of ascites, lower CA125level in type I EOC patients. It is suggested that type I EOC and type I EOC had different clinical and pathological characteristics. The "dualist model" can actually refract the prognosis of two types of epithelial ovarian cancer and present a potential value in clinical application.