A Retrospective Clinical Study Of Chemotherapy In 64 Patients With Epithelial Ovarian Cancer

OBJECTIVE: To evaluate the activity, toxicity,one—year survival rate and cost of chemotherapy with paclitaxel and carboplatin in epithelial ovarian cancer at the Department of Obstetrics and Gynecology, the First Hospital of Ji Lin University.METHODS: A retrospective analysis of 34 women with epithelial ovarian cancer diagnosed from January 2006 to December 2007 was performed at the Department of Obstetrics and Gynecology,the First Hospital of Ji Lin University, whom were treated with carboplatin-paclitaxel chemotherapy(TC). And compare them with 30 women diagnosed from January 2000 to December 2007 treated with carboplatin-Cyclophosphamide chemotherapy(CC).RESULTS: There were 25 complete responses (CR) and 4 partial responses (PR) for an overall response rate (RR) of 85.59% in the TC group. While there were 14 complete responses (CR) and 2 partial responses (PR) for an overall response rate (RR) of 53.33% in the CC group(X~2=7.7991, P<0.01). The most frequent toxicities in TC were nausea, alopecie and debility, each incidence was 100%. 5 patients who vomited needed agentia to stop vomiting. Complete alopecie appeared in 15 patients, whose hair could regenerate in 2—3 months after chemotherapy stopped. Next toxicity is grade 1&2 aleucocytosis(25). Occasionally, other toxicities occurred. For example, higher aminopherase was reported in 7 patients, higher BUN in 5, bloody urine in 5, proteinuria in 1, alimentary tract hemorrhage in2, deadlimb in 3, diarrhea in 2, constipation in 1, itch of skin in 1. Cardiotoxic was not reported. In CC group, nausea or vomiting was reported in 26 patients, in which 3 needed agentia to stop vomiting. Debility occurred in 26 patients while alopecie occurred in 17 patients, incidence of which showed lower than that in TC group(X~2=18.488, P<0.01). Complete alopecie appeared in 3 patients,whose hair could regenerate in 2-3 months after chemotherapy stopped. The incidence of aleucocytosis(complete grade 1&2 aleucocytosis)in CC group was 43.33%, which was lower than that in TC group(X~2=6.0245, P<0.05). In CC group, higher aminopherase was reported in 5 patients, alimentary tract hemorrhage in 2, higher BUN in 3, bloody urine in 5, proteinuria in 4, diarrhea in 1, constipation in 4, sensitization dermatitis in 1. One-year survival rate in TC group was 95.56%, in CC group was 93.33% (X~2=5.6456, P<0.05). TC cost much more than CC in hospital (t=12.561, P< 0.01).CONCLUSION: (1) Overall response rate of TC is highter than CC. (2) The most frequent toxicities in TC were nausea, alopecie and debility. Next toxicity is grade 1&2 aleucocytosis. The incidence of alopecie and aleucocytosis was higher than CC. Higher aminopherase, higher BUN, deadlimb, diarrhea, constipation and inch of skin were reported occasionally. (3) The one-year survival rate of TC is higher than CC. (4) TC costs much more than CC in hospital.