| Objective:By means of random control experiment, we observe the difference of clinical efficacy after respectively using acupuncture and Climen in treating dyslipidemia and peri-menopausal period syndrome in order to provide reliable evidence to apply acupuncture rather than hormonotherapy in treating the mentioned disease and further the clinical popularization and application of the acupuncture therapy.Methods:Recruit 72 up-to-research-standard patients with dyslipimedemia and peri-menopausalperiod syndrome. Then randomly divide the subjects into two groups(each 36 subjects)-----the acupuncture group and the medicine group. The acupuncture group are acupunctured Guanyuan acupoint, Zigong acupoint, Zusanli acupoint, Sanyinjiao acupoint, etc, together with Er acupoint, lasting for 12 weeks continuously. For the first 4 weeks, the subjects are acupunctured times a day; For the last 8 weeks, twice per week------28 times in all. As for the Er acupoint, the subjects are acupunctured twice a week every 2 or 3 days. Both ears are acupunctured alternatively. This treatment covers 24 times in all. The medicine group take one Climen a day, lasting 21 days on end, which includes 3 periods. And use the Menopause Rating Scale (MRS) as the evaluating indicator and E2, FST, TC, TG, LDL-C, HDL-C, Apo-A, Apo-B as the observational indicator. Test the indicators at the beginning and after 12 weeks. And then evaluate the difference of efficacy between acupuncture therapy and hormonotherapy.Results:1. Two basic line indicators----age, disease level, MRS, sex hormones level, blood fat level-----have no difference in statistics. The two basic lines are balanced.2. After 12 weeks, each subject’s numerical values of MRS have dropped sharply in both groups. The changes have statistic meaning(p<0.05). However, there is no remarkable difference between the two groups in terms of the numerical values(p>0.05).3. Comparison of the sex hormones levels. After treatment, in the acupuncture group, the value of E2 has risen slightly. The change has statistic meaning(p<0.05). But the change of FSH is not that big, with no statistic meaning(p>0.05). In the medicine group, the value of E2 has risen sharply. The value of FSH has fallen remarkably. The changes have statistic meaning(p<0.05). Comparing the two groups, the changes of the values have statistic meaning(p<0.05).4. Comparison of blood fat levels. After treatment, in the acupuncture group, the numerical values of TC, TG, LDL-C have dropped sharply, whereas the value of HDL-C has risen sharply. These changes have statistic meaning(p<0.05). Nevertheless, the changes of Apo-A, Apo-B have no such meaning(p>0.05). As for the medicine group, the numerical values of TC, TG, LDL-C, Apo-B have fallen sharply. The changes have statistic meaning(p<0.05). The values of HDL-C, Apo-A have risen sharply. The changes have statistic meaning(p<0.05). By comparison, the differences in TG, HDL-C, LDL-C have no statistic meaning(p>0.05), while the differences in TC, Apo-A, Apo-B, have statistic meaning(p<0.05).5. Comparison of safety. Remarkably,the side effects in acupuncture group have occurred less than those in the medicine group. Thus, the acupuncture therapy is much safer.Conclusion:1. Both acupuncture and Climen can effectively reduce the ratings of MRS and greatly improve other syndromes related to peri-menopausal period syndrome.2. To some degree, acupuncture can adjust the levels of sex hormones and blood fat of patients with dyslipimedemia and peri-menopausal period syndrome. But Climen is more effective.3. Acupuncture is effective in treating dyslipimedemia and peri-menopausal period syndrome and is safer than Climen,so Itis worthapplied inclinical practice. |
PDF Full Text Request