The Connection Between Creatine Kinase And Blood Pressure And Some New Progress Of Creatine Kinase Inhibition In The Treatment Of Hypertension

Creatine kinase (CK) is one of the central regulatory enzymes in cellular energy metabolism. It has been demonstrated that CK activity is associated with blood pressure. The enzyme may be involved in vascular pressor response by improving myocardial and resistance artery contractility and increasing sodium retention as well as inhibiting nitric oxide-dependent endothelial functions. CK is associated with failure of antihypertensive therapy,it may be a prognostic marker in the treatment of hypertension. Beta-guanidinopropionic acid β-GPA) can reduce the flux of the CK by competitive inhibition of cellular creatine uptake, which may be a new way to decrease blood pressure. In this paper, we systematically review the connection between CK and blood pressure and the application of β-GPA in the treatment of hypertension.