Correlation Analysis Of Lower Extremity Atherosclerosis And Cardiovascular Risk Factors In Elderly

Objective:To investigate the correlation between lower extremity atherosclerosis disease (LEAD) and cardiovascular risk factors in the elderly.Methods:A total of 700 consecutive patients in Gerontology Department with lower extremity arterial ultrasound were enrolled in this study from May 2013 to November 2014, divided into young adult, elderly and senile group according to age. Based on the lower extremity arterial ultrasound results, the severity of atherosclerosis were divided into normal, mild, moderate, and severe sclerosis four groups. Collected enrolled patient’s age, sex, height, weight, history of smoking, hypertension and diabetes mellitus, body mass index (BMI)=kg/m2. All of them were measured SBP, DBP, TQ TC, HDL-c, LDL-c, FBG,2hPBQ HbAlc, Fib, Cr, UA, hs-CRP and ABI. We compared respectively the characteristics of the risk factors in various age groups and different severity of LEAD, and analyzed their relevance.Results:Multivariate unconditional logistic regression analysis showed that advanced age, smoking, diabetes mellitus, UA, ABI are independent risk factors for LEAD (all p<0.05). Ordinal logistic regression analysis showed that advanced age, male, smoking, UA, ABI and hypertension were correlated with severity of atherosclerosis (all p<0.05). Compared with the young adult, moderate and severe arteriosclerotic lesions rate are significantly higher in elderly and senile group, that also higher in senile than in elderly group (all p<0.01).With increasing age, the severity score of LEAD increased (p<0.01).Conclusions:Compared with the young adult, LEAD in elderly patients are heavier. The risk factors of aging, smoking, diabetes mellitus, UA and ABI are independently correlated with LEAD, and advanced age, male, smoking, UA, ABI and hypertension are closely related with the extent of LEAD in the study.