Ramulus Mori Total Alkaloid In The Treatment Of Type 2 Diabetes (Damp Heat Trapped Spleen Syndrome) Clinical Observation

Objective:Observation of ramulus mori total alkaloid piece of treatment in patients with type 2 diabetes (damp heat trapped spleen syndrome) clinical efficacy and safety.Method:Selection of heilongjiang university second affiliated hospital of traditional Chinese medicine in July 2014 to March 2015, western medicine diagnosis of type 2 diabetes and syndrome differentiation of traditional Chinese medicine is a hot and humid trapped spleen syndrome 32 cases of clinic patients, randomly divided into 2 groups, experimental group 16 cases, control group 16 cases. Using random mating, double-blind, placebo parallel control method of observation of ramulus mori total alkaloid tablets in patients with Chinese medicine symptom integral, HbA1c, FPG,1 hPBG,2 h PBG, blood lipid curative effect index and related safety index.Results:1. The efficient comparison:the treatment group effective rate was 75%, the control effective rate of 28.57%, comparing the two groups P< 0.05, the difference was statistically significant.2.TCM symptoms curative effect comparison:TCM symptoms in treatment group total score compared with the control group P< 0.05, the difference was statistically significant. TCM symptoms in treatment group compared with the control group in the chest often single integral food after abdominal distension and full and head body weight, heart annoyed, limbs burnout single score before treatment after treatment P< 0.05, the difference was statistically significant.3.HbA1c comparison:after treatment the treatment group compared with control group patients glycosylated hemoglobin (P< 0.05, the difference was statistically significant.4.The FPG,1 HPBG,2 HPBG comparison:the treatment group and control group after treatment of FPG,1 HPBG,2 HPBG, P< 0.05, the difference was statistically significant.5.Lipid comparison:treatment group and control group before treatment lipid result comparison, P> 0.05, before treatment, there was no statistically significant difference was comparable; After treatment, compared two groups of blood fats, P< 0.05, the difference was statistically significant.6.Safety index comparison:the treatment group compared with control group two groups before and after treatment, liver, kidney function has no obvious statistical significance difference; Electrocardiogram (ecg) before and after the treatment, routine blood and urine, no abnormal change.Conclusions:1. Ramulus mori total alkaloid tablets in patients with type 2 diabetes (damp heat trapped spleen) of TCM symptoms of chest often food after abdominal distension and full and head body weight, heart annoyed, limbs burnout has improved significantly.2. Ramulus mori total alkaloid tablets in patients with HbA1c,FPG,1 HPBG,2 HPBG have improved significantly.3. Ramulus mori total alkaloid tablets in patients with blood lipid have improved significantly.4. Ramulus mori total alkaloid piece of treatment in patients with type 2 diabetes (damp heat trapped spleen syndrome) with security.