| Objective:this study through the observation of Zishengwan ointment about clinical curative effect for the treatment of childhood bronchial asthma with lung-spleen qi deficiency.Methods:actually conform to the children’s asthma of the lung-spleen qi deficiency of 69 cases were randomly divided into 35 cases of the treatment group and 34 cases of the control group. The treatment group:the Zishengwan ointment. The control group:Montelukast. Two groups of 5-14years old with childhood asthma,3 months for a period of treatment. Follow-up 3 months.After treatment for one month, compared clinical curative effect of the two groups before and after treatment, Chinese medicine symptom integral, small airway function recovery condition, situation of PEF and FEV1 before and after treatment,compared with numbers of asthma attacks and the status of the quality of life.After the treatment, two groups of children’s asthma observe the situation of the recurrence rate and security monitoring in follow-up 3 months. Application of SPSS19.0 or SAS 8.1 statistical software for data analysis.Results:1. The clinical curative general consequence. The treatment group after treatment clinical recovery in 9 cases(25.71%), significant effect in 17 cases(48.57%),effective in 8 cases(22.86%), effective invalid in 1 case(2.86%). Control group after treatment clinical recovery in 5 cases(14.71%),significant effect in 9 cases(26.47%), effective in 15 cases(44.12%), effective invalid in 5 cases (14.71%), and markedly effective rate of treatment group was 74.30%, the control group 41.20%, the treatment group superior to the control group(P<0.01); And two group total effective rate by comparison, there was no statistically significant difference(P>0.05);2.Single symptom integral situation of TCM. Treatment group after treatment was better than before treatment (P<0.05), statistically significant and between groups in treatment group and control group are also statistically significant (P<0.05).3.The lung function. Small airway function index such as FEF25%, FEF50%, FEF75%,MMEF75/25% after treatment were better than that of before treatment (P<0.05), and the treatment group is better than that of control group(P<0.05), statistically significant, and PEF and FEV1 in the before and after treatment, there was no significant difference(P>0.05).4. The number of attack of children’s asthma. The treatment group the number of attack of children’s asthma (3.54±1.27) times decreased to (0.51±0.51) times, and the control group (3.76±1.33) times decreased to (1.38±0.60) times, the statistical comparison, the treatment group is better than that of control group (P<0.01), after treatment is better than that of before treatment (P<0.01), statistically significant difference;5. The quality of life of children’s asthma. Quality of life of childhood asthma by the treatment group (2.00±0.41) increased to (3.45±0.39), while the control group (1.99±0.51) increased to (2.67±0.41), and the treatment group is better than that of control group (P<0.01), after treatment is better than before treatment (P<0.01), the difference is statistically significant.6. The recurrence rate of children’s asthma.After the treatment,the numbers of children’s asthma randomly drawn from the treatment group and the control group with clinical recovery and significant effect in follow-up 3 months. The treatment group in 18 cases,3 cases of recurrence, the recurrence rate in 16.67%; the control group in 11 cases,8 cases of recurrence, the recurrence rate in 72.73%. The recurrence rate compared the two groups, the treatment group was better than control group, difference has statistical significance(P<0.01).7. The security situation of two groups. Each check indicators of two groups to detect no obvious abnormalities. And adverse reactions of treatment group and control group, there was no significant difference(P>0.05)Conclusion:1.Zishengwan ointment treatment of children’s asthma markedly effective rate74.30% was better than control group 41.20%;2.Zishengwan ointment treatment of children’s asthma with lung-spleen qi deficiency about improving single symptom integral situation of TCM is better than control group;3.Zishengwan ointment improve small airway function was better than control group, but to improve the function of main airway, such as PEF,FEV1, there was no significant difference;4.Zishengwan ointment improve the number of attack of children’s asthma is superior to control group;5.Zishengwan ointment improve quality of life of children’s asthma obviously better than the control group.6.Zishengwan ointment control asthma relapse is superior to the control group.7.Zishengwan ointment better compliance, adverse reactions in treatment group compared with control group, there was no significant difference. |
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