| Objective To investigate the prevalence rates, epidemic characters and risk factors of hyperhomocysteinemia(HHcy),explore the relations of them with HHcy diseases among rural Kazakh and Uyghur adults in Xinjiang,Explore the relationship between Hyperhomocysteinemia with hypertension and diabetes,Provide basic data for further study of homocysteine,provide the scientific basis for preventing and controlling the pathogenesis of cardiovascular and cerebrovascular diseases.Methods Questionnaire-based survey during the face to face interview,physical examination,fasting plasma glucose and blood lipids for 7211 samples were conducted according to stratified cluster random samplings in Kazakh and Uygur residents aged 25 years in Yili Xinyuan County and Kashi Jiashi County in Xinjiang during 2009 and 2010 year. To meet the required sample size and Hcy detect funds problems, after stratification by sex and age through proportional random sampling and other random number tables, we selected a total of 1,003 cases and 1,177 cases from the Kazakh and Uyghur populations, respectively, as the subjects for this study. A databank was created using Epi Data software(Epi Data Association, Odense, Denmark, http://www.epidata.dk/). The data were analyzed using SPSS(Statistical Program for Social Sciences, version 17.0, 2008). The continuous variables were presented as means ± standard deviations(M±SD) and analyzed using a t-test. The serum Hcy levels displayed a positively skewed distribution. After a logarithmic(lg10) transformation, the data were approximately normally distributed with a geometric mean(G) and corresponding 95% confidence intervals(95% CI) on behalf of the serum Hcy average. The categorical variables were expressed as numbers or percentages and were analyzed using the Chi-square test and trend test. All the statistical tests were two-sided, and the differences were considered statistically significant when the P value <0.05.Results 1.According to the American Heart Association and the " Chinese Hypertension Prevention Guide(2011 edition)," a common standard diagnostic classification Hyperhomocysteinemia, the level of Hcy in Kazakh and Uighur rural was 13.3(9.2~19.4) and 13.7(8.8~21.40)μmol/L, HHcy prevalence was 80.0 % and 78.2%, respectively, HHcy male prevalence was 93.5 % and 90.8%, respectively,Except the age group of 35~, The prevalence of HHcy in Kazakh was higher than in Uighur(P <0.05), Hyperhomocysteinemia prevalence of both ethnic differences among the rest age groups of men was not statistically significant. The prevalence of female HHcy was 69.6 % and 64.4% among Two ethnic,Except the age group of 35~ and age group of 55~,The prevalence of HHcy in Kazakh was higher than in Uighur(P <0.05), Hyperhomocysteinemia prevalence of both ethnic differences among the rest age groups of women was not statistically significant.2.The male prevalence of HHcy was higher than that of females among both ethnicities. The male prevalence of H-type hypertension was higher than that of females among both ethnicities.(p<0.05)3.The prevalence of two ethnic HHcy has increased with age trend(P<0.01). 4.For Kazakh population,ages increasing will increase the risk of HHcy,and Sex for women were the opposite;Uighur people, ages increasing and hypertension will increase the risk of HHcy, and Sex for women were contrary.5.The overall prevalence rate of Kazakh rural residents with hypertension,diabetes was 40.1% and 10.0%,the Uighur’s corresponding rates were 34.7% and 4.5%.The prevalence of hypertension and diabetes in Kazakh and Uighur rural residents have increased with Hcy increasing trend(P<0.05);and HHcy will increase the risk of two chronic diseases compared with normal Hcy status.(Diabetic in Uygur were except).Conclusions HHcy was common among the Kazakh and Uyghur. The prevalences of HHcy and H-type hypertension were high among the Kazakh and Uyghur and differed depending on gender and age. Community interventions should be conducted to improve public health conditions among the Kazakh and Uyghur in Xinjiang.Conclusion 1.The prevalence of HHcy and the levels of Hcy in Kazakh and Uighur rural residents was at a high level, and the prevalence of H-type hypertension in Kazakh and Uighur rural residents also was at a high level. 2.The prevalence of Kazakh and HHcyt in men were higher than women, HHcy in two ethnic have increased with age trend. 3.The risk factors for HHcy in Kazakh population was age and sex for men;the risk factors for HHcy in Uighur population were age,the sex for men and hypertension. 4.The prevalence of hypertension and diabetes in Kazakh and Uighur rural residents have increased with Hcy increasing trend;and HHcy will increase the risk of two chronic diseases. |
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