Clinical Observation Of Jiawei Chaihu Plus Longgumuli Particles In The Treatment Of Wind Phlegm Closed Orifices Epilepsy(generalized Tonic- Clonic Seizures)

Objective: To observe the clinical curative effect and security of wind phlegm closed orifices epilepsy(generalized tonic- clonic seizures) treated by Jiawei Chaihu plus longgumuli particles combined antiepileptic medicine,To investigate the mechanism of Jiawei Chaihu plus Longgumuli particles in the treatment of wind phlegm closed orifices epilepsy(generalized tonic- clonic seizures)epilepsy,Provide theoretical support for clinical applications.Method: This study is a randomized controlled clinical study.From 2013 January to 2015 January screening clinic in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, encephalopathy three districts epilepsy outpatients,The 60 patients met the inclusion criteria wind phlegm closed orifices epilepsy(generalized tonic- clonic seizures) were randomly divided into two groups.The control group received conventional Western antiepileptic therapy,The treatment group on the basis of conventional therapy,To be taken orally jiawei Chaihu plus Longgumuli particles.The two groups were observed for one year.Before and after treatment through clinical observation by self,Quality of life in epilepsy inventory(QOLIE-31) to observe and record the number of epileptic attack,Clinical symptoms and signs and the quality of life in patients with epilepsy.After the end of treatment,From the number of seizures in patients with epilepsy,Seizure frequency,Adverse drug reaction,achieve the effective blood drug concentration and the quality of life of patients with epilepsy before and after treatment to evaluate the clinical efficacy of the treatment of epilepsy.Statistical data analysis using computer spass19.0 version software for processing.Results:(1)General information on the differences between the two groups of patients:Using chi square test, t test and rank sum test for the two groups in sex, age,course of disease analysis,The results showed no significant difference between the two groups of patients and were comparable(P>0.05).(2)Two groups of patients before treatment of seizures, seizure frequency,clinical symptoms,the quality of life of patients with epilepsy were compared,By t test P>0.05,Two groups of patients were comparable.(3)Two groups of patients after treatment of seizures, seizure frequency, clinical symptoms,the quality of life of patients with epilepsy were compared,the treatment group was superior to that in the control group and there were significant differences(P <0.05).(4)Complete situation and Safety observation :The treatment group of 30 cases,There are two cases in which the patient off for economic reasons,Completed 28 cases,None of the patients had obvious adverse reaction;The controlt group of 30 cases,1 patient lost to follow and fall off,Two cases of serious adverse reactions due to the termination of the test,Completed 27 cases.Conclusion:(1)The clinical curative effect of Jiawei Chaihu plus Longgumuli particles combined with anti-epileptic medicine treatment of wind phlegm closed orifices epilepsy(generalized tonic- clonic seizures) is obviously superior to the single use of anti-epileptic medicine,It can not only reduce the number of seizures,To reduce the frequency of attacks in patients,Improve the patient’s clinical symptoms and signs,Significantly reduce the adverse reactions of patients,But also greatly improves the quality of life of patients.(2)Whether to achieve effective blood concentration range,Compared the clinical efficacy of the two groups,The treatment group was better than the control group, Less adverse reactions and the treatment group of patients,To a lesser extent.