Detoxification Living Blood Contact Through The Early Diabetes Lower Extremity Angioedema Clinical Integrated Intervention And The OPG Expressed The Impact

Purposes:This article is for the purpose of from “the stasis poisonous wound and the vein” discusses governs the early diabetes lower limb blood vessel pathological change, the cause of disease pathogenesis and the function mechanism which the discussion book gets sick, and establishes “the disintoxicating blood circulation passes winds” the treatment principle, plans Cheng Tangmai by this to be skilled in magical arts, and discusses the research sugar arteries to pass to the early diabetes lower limb blood vessel pathological change synthesis intervention function and to the blood serum bone protection element(OPG) expression, for the Chinese medicine dialectical treatment early time diabetes lower limb blood vessel pathological change, improves its curative effect, provides the new theory and the clinical research material, provides the new theory basis take the time as clinical treatment this sickness and governs the France side medicinal preparation.Method:1. Clinical studies: The 100 patients randomized to treatment and control groups two groups, the treatment group with sugar pulse-based party, in conjunction with acupuncture and Chinese medicine, money, and methods for integrated intervention treatment; control group based on the basis, to West, he zolpidem treatment, the sugar pulse through the early diabetes leg angioedema patient blood sugar, blood fat, ankle brachial, intermittent limp distance, limb elevation, such as the impact indicators.2. experimental study: the 40 model of diabetic rats were randomly divided into groups, Mai Tong small dose of sugar, sugar, pulse through high-dose group, control group into four groups, 10 rats in each group, and another 10 in normal rats in the control group. Model group: with saline 10mL/kg irrigation stomach; sugar pulse pass small dose group: in gives gliclazide 20 mg/treatment of based Shang, with sugar pulse pass water fried agent(concentration for 2g/mL) 10 mL/kg irrigation stomach; sugar pulse pass big dose group: in with gliclazide 20 mg/kg treatment of based Shang, gives sugar pulse pass water fried agent(concentration for 4g/mL) 10mL/kg irrigation stomach; Western control group: in with gliclazide 20 mg/kg treatment of based Shang, Granting of suspension of cilostazol(concentration of 1.8 mg/mL) 10mL/kg IG. Control group: with an ordinary feeding, use equal amounts of sterile sodium citrate buffer solution by intraperitoneal injection, blood glucose is between 4.7-7.3mmol/L, with the volume of distilled water. Observe the blood glucose, blood lipid and vascular ultrastructural changes and expression of OPG.Finally:1. clinical studies: dominated by sugar Tong’s comprehensive clinical intervention can improve the symptoms and signs of patients with diseases and abnormal blood glucose, blood lipid and other indicators also improved, such as intermittent claudication distance, ratio of ankle-brachial effect are better than the control-group.2. Experimental study: The sugar arteries pass can enable diabetes model big targets and so on mouse’s blood sugar, blood fats, saccharification hemoglobin to be improved, simultaneously it also distinct improvement model big mouse’s blood vessel structure exceptionally change, as well as to the OPG expression, its curative effect surpassed the western medicine control group.Conclusion:Through clinical and experimental study show that: with jiedu huoxue t2 dm method for the treatment principles of sugar vein for early diabetic lower extremity vascular lesions of clinical comprehensive intervention treatment effect is remarkable,Take detoxifies the blood circulation to pass winds as the method of treatment, composes the sugar arteries pass, not only can improve the early diabetes lower limb blood vessel pathological change patient’s symptom symptom, moreover can improve the malleolus brachium compared to, total target and so on cholesterol, triglyceride levels, its method safe effective, to enhances the lower limb activity to have the distinct improvement function, is worth studying and the promotion thoroughly.