The Observation Of Row Of Thrust Acupuncture And Rizatriptan And The Combine Of Both For Synergistic Analgesia Therapeutic On Acute Stage Of Migraine Without Aura

Migraine, one of the most common primary headaches, causes heaven economic burdens and huge impacts for individuals and society worldwide for its high prevalence and disability. Though there are numerous treatment for migraine and the therapeutic effects are moderate, most of them are susceptible to multiple factors. Thus, it is imperative to preliminary optimize the methods for migraine attack by comparing various treatment methods. Objective:For preliminary optimization of therapeutic regimen on patients with migraine without aura.Methods:A total of 90 migraineurs during attacks were randomly assigned into three arms. The first group received treatment of row of thrust acupuncture, the acupoints were Naohu (DU17) and affected side Naokong (GB19), and the treatment was last for 6 hours once as a session. The second group was treated with 10mg rizatriptan, it could be repeated once if the pain lasted, and the treatment was once a session. The third group combined both methods. The primary evaluating index was the proportion of responders, which was defined as at least 50% of participants with a headache relief by visual analog scale (VAS) scores 2h after treatment. The secondary evaluating indexes included the improvement of the VAS scores during attacks at the present,0.5,2 and 6 hours after treatment, and the proportion of participants with the headache disappeared after 2 and 6 hours’treatment.Results:There were no significant differences intergroup for the proportion of responders with a headache relief of VAS scores by at least 50%(P>0.05). For the improvement of the VAS scores during attacks at the present, significant differences were also found intergroup. The first group and the third group were better than the second group (P<0.05). For the improvement of the VAS scores during attacks at the 0.5 hour, the third group was better than the second group (P<0.05).For the improvement of the VAS scores during attacks at the 2 hours, the third group was better than the first group (P<0.05). For the improvement of the VAS scores during attacks at the 6 hours, the third group was better than the other two groups (P<0.05). And the third group showed better result than that of the second group (P<0.05) for the proportion with a headache disappeared after 6 hours.Conclusions:Treatment combined with acupuncture and rizatriptan showed slightly better ttherapeutic effect than the other two groups for the primary outcome; nevertheless, there were no significant differences intergroup. For the secondary outcomes, the acupuncture and the combination therapy were better than rizatriptan at the present; The combination therapy was better than rizatriptan at the 0.5 hour. The combination therapy was better than the acupuncture at the 2 hours. The combination therapy was better than the other two groups at the 6hours. And the combination therapy was better than the rizatriptan group at the proportion with a headache disappeared after 6 hours.