The Correlation Analysis About Sex Hormones、Menstrual And Epilepsy In Childbearing Age Women With Epilepsy

Objective Through the clinical analysis of 72 cases of childbearing age women with epilepsy, understanding the impact of epilepsy to menstruation and sex hormones in childbearing age women with epilepsy, and discussing the influence factors of female catamenial epilepsy.Methods According to the inclusion and exclusion criteria, Epilepsy group included 72 childbearing age women with epilepsy, from October 2014 to March 2015 in the first affiliated hospital of kunming medical university neurology outpatient and the inpatient treatment. Healthy controls group match epilepsy group with the age of patients’family members, medical personnel and other healthy people in 70 cases. For female epilepsy patients, collected the clinical information of epilepsy, and finished the sex hormone determination, the head MRI and video or 24 hours dynamic electroencephalography examination. For other healthy women, asked them about menstrual conditions. Using statistical methods to analyze the impact of epilepsy to menstruation and sex hormones in childbearing age women with epilepsy, and the related risk factors of menstrual disorders for women with epilepsy. Analyzing the correlation between catamenial epilepsy and various sex hormones, and the relative influencing factors of catamenial epilepsy.Results 1, The epilepsy and menstruation situation:Women with epilepsy was easier to appear menstrual disorders than healthy women. The epilepsy women with seizures frequency>3 times/half a year, multi-drug treatment or head MRI and EEG examination positive have a high incidence about abnormal menstruation than the epilepsy female patients with seizures frequency≤3 times/half a year, monotherapy, or head MRI and EEG examination negative(P<0.05).Frequent seizures and head MRI showed intracranial lesions were risk factors for menstrual disorder of women with epilepsy (B>0,OR>1,P<0.05).And frequent seizure was the most important influenced factor to menstrual disorder of the women with epilepsy.2,The epilepsy andsex hormone:follicle-stimulating hormone was associated with age(P<0.05). Luteinizing hormone was associated with cranial MRI results(P<0.05). Prolactin was associated with seizure frequency((P<0.05). Testosterone was associated with progression and attack frequency(P<0.05). Estrogen was associated with seizure frequency(P<0.05).Female progesterone and E2/P were associated with seizure frequency, age and seizure types(P<0.05).3, The seizure frequency, E2/P and prolactin,estrogen level of female menstrual epilepsy patients were higher than the female epilepsy patients have no relationship to menstruation,and the progesterone are lower(P<0.05). Female catamenial epilepsy related to the level of estrogen (B>0,OR>1,P<0.05),and progesterone in blood circulation(B<0,OR<1,P<0.05).Conclusions 1, Women with epilepsy was easy to appear menstrual disorders, especially in the temporal lobe epilepsy, in addition, the more frequently the seizure, the higher the incidence of menstrual disorders.2, Women with epilepsy was easy to appear abnormal sex hormone secretion, and sex hormone secretion was influenced by many factors, including age, course of epilepsy, seizure frequency, intracranial lesions, and the sample epilepsy discharge.3, In this study, about 43.05% of the patients in the study seizures was associated with menstrual cycles, of which around the onset of menstruation was the majority.4, The important factors to catamenial epilepsy in female patients were estrogen and progesterone level which changed by menstruation periodic in women. And because of frequent seizures, the catamenial epilepsy were harder to control.