The Effects Of Zhizhu Wing Stomach Granules On Plasma Mot, CAS And PG Of CAG Of Patients And The Clinical Study On Efficacy Of Zhizhu Wing Stomach Granules In Treatment Of Patients With CAG

Objective:In clinical research proposed on the basis of,by observing Zhizhu Wing stomach granules on patients of spleen deficient and qi stagnation syndrome and chronic atrophic gastritis(CAG) with the clinical symptoms,the degree of gastroscopy atrophy,pathology atrophy and intestinal metaplasia degree,H.Pylori(Hp)removal,case recurrence of symptoms afte treatment, plasma motilin(MOT),gastrin(GAS),pepsinogen(PGⅠ,PGⅠ/PGⅡ)effects,as well as to evaluate its clinical efficacy and safety and explore the mechanism,so we can find effective treatment method and optimization scheme of traditional Chinese medicine for chronic atrophic gastritis and provide more scientific theory basis for clinical application and new drug development.Methods: 66 patients were randomly divided into two groups:the treatment group incl uding 33 cases and control group with 33 cases.The control group was given Weifuc hun piece.The treatment group was given Zhizhu Wing stomach granules(Citrus auran tium, fried Atractylodes,Pericarpium citri reticulatae, Ginger Pinellia Woody,August Sa pporo,Curcuma,Poria,Areca,Zhigancao). Therapy were 12 weeks for a course of treatm ent, one course totally,after treatment followed up for 12 weeks. Indicators were me asured before and after treatment, a total of two times.After observation for the stati stical processing of indicators.Results:(1)Comparison of the total curative effect: treatment group Clinical cure 9 cases, markedly effective 9 cases, effective 8 cases, invalid 7 cases, the total efficiency of 78.79%; control group Clinical cure 4 cases, 7 cases markedly effective, effective 9 cases, invalid 15 cases, the total efficiency of 54.55%. There is significant difference between the two groups(P<0.05).(2)Comparison of therapeutic effect of syndrome: 13 cases of clinical cure, 9 cases markedly effective, effective in 8 cases, invalid 3 cases,the total efficiency of 90.91%; control group 7 cases were cured, 9 cases markedly effective, effective 7 cases, invalid 10 cases, the total effective rate was 69.70%. There is significant difference between the two groups,difference between two groups(P<0.05).(3)Comparison of efficacy of endoscopic: treatment group Clinical cure 10 cases, markedly effective 10 cases, effective 8 cases, invalid5 cases, the total efficiency of 84.85%; control group Clinical cure 4 cases, 9 cases markedly effective, effective 8 cases, invalid 12 cases, the total efficiency of 63.64%. There is significant difference between the two groups(P<0.05).(4)Comparison of the efficacy of Pathology:9 cases of clinical cure, 9 cases markedly effective, effective in 9 cases, invalid 14 cases,the total efficiency of 81.82%; control group 5 cases were cured, 7 cases markedly effective, effective 7 cases, invalid 12 cases, the total effective rate was 57.60%. There is significant difference between the two groups,difference between two groups(P<0.05).(5)Hp clearance rate comparison: the treatment group, 26 cases of clinically effective, ineffective in 8 cases, the total efficiency of 78.79%, in the control group clinically effective 18 cases, ineffective in 16 cases, the total efficiency of 54.55%, the difference between the two groups was significant(P <0.05).(6)Plasma motilin(MOT), gastrin(GAS) and pepsinogen(PGⅠ, PG / PGⅠ Ⅱ) comparison of efficacy: a significant increase in both groups MOT, GAS and PGⅠand PG / PG after treatment(P <0.01). GAS aspeⅠ Ⅱ ct in improving patient treatment group and the control group had no significant difference(P> 0.01). In improving the patient’s MOT, PGⅠand PG / PG aspects of the treatment group than the control group Ⅰ Ⅱ(P <0.01).(7)Comparison of safety: the two groups during treatment, no obvious adverse reactions were found, blood routine, urine routine, stool routine, renal function and liver function before and after treatment, and there were no abnormal changes of ECG were associated with drugs.(8)after treatment followed up for 12 weeks,whether the symptoms recurred: In the treatment group, one patient developed epigastric discomfort, but in the control group, there were six cases. The two groups’ follow-up and after-treatment upon Statistical test, in the treatment group for comparison of therapeutic effect of syndrome, there were no significant differences statistically significant(P> 0.05);but in the control groups, the difference was significant statistically significant(P <0.05),thus we concluded that the treatment was more stability and less recurrence rate than the control group.Conclusion:(1)Zhizhu Wing stomach granules have better clinical efficacy on patients of spleen deficient and qi stagnation syndrome and chronic atrophic gastritis(CAG),the total curative effect is better than control group;(2)It can obviously reduce the patients’ clinical symptoms and signs, improve their quality of life;(3)It can significantly improve the patients’ endoscopy and histological aspects;(4)It can significantly remove H.Pylori infection;(5)It can significantly adjust the level of plasma motilin(MOT), gastrin(GAS), plasminogen(PGⅠ, PG Ⅰ/ PGⅡ);(6)It can reduce and prevent the patients of spleen deficient and qi stagnation syndrome and chronic atrophic gastritis(CAG)symptoms relapse, Safely and effectively,can become the ideal treatment of traditional Chinese medicine.The mechanism may be related to pathogenic microorganisms, enhance the body immunity, regulate gastrointestinal hormones, improve gastric mucosal blood flow, anti-tumor and so on.