The Clinical Study On The Treatment To The Diabetic Constipation With Jiangtangtongbian Pills

Background: Diabetes mellitus(DM) is elevated metabolic disease characterized by hyper-glycemia. At present, the prevalence rate of diabetes rose sharply in China, according to the International Diabetes Federation(IDF) statistics, the global DM patients has reached 370,000,000 in 2011,and 80% of them in developing countries, estimates that by 2030 the world will have nearly 550,000,000 of DM patients. But diabetes constipation is the common clinical manifestations of diabetic autonomic neuropathy(DAN), according to relevantstudies show, about 2/3 of DM patients can produce constipation, about 90% with obviousdiabetic neuropathy in patients with different degree of constipation performance. Constipation not only seriously affects the life quality of the patients, but also increase the difficulty of blood glucose control, occurrence, development and ultimately can accelerate DM complications. Therefore, effective prevention of diabetic constipation has become an important means of treatment of DM. Chinese medicine treatment theory guidance in thesyn-drome differentiation,in the long-term clinical treatment of this disease has accumulated rich experience.Objective:To observe the hypoglycem icaperien pills,TCM syndrome integral of diabetic constipation symptoms of fasting blood glucose(FBG), 2 hour postprandial blood glucose(2h BG), the influence of blood lipid and other related indicators, to summarize the cli-nical effect of glucose lowering aperient pill in the treatment of diabetic constipation.The ef-fect and the mechanism and to explore the hypoglycemic aperient pills, Provides the scientific theoretical and practical basis for the clinical application and development of new drugs. Methods: all the data are from 2014 May to 2015 February, Henan University of Traditional Chinese Medicine affiliated Kaifeng hospital observation(diabetes treatment center combin-ing Chinese and Western medicine in Henan province) ward or outpatient, consistent with thediagnosis of diabetes constipation were included in a case 63,were randomly divided intot-reatment group and control group. The treatment group of 31 cases, 32 cases of the control group. There were no significant difference between the age, gender, disease duration, eachc-omplication(P > 0.05). In the conventional treatment(the law of life, the diabetes diet,positive control of blood sugar,including oral hypoglycemic agents(not including traditi-onal Chinese Medicine) or insulin injections, drugs do not use any other interference gastric motility) basis, the treatment group: oral glucose lowering aperient pills 5 pills(3G) Tid(He-nan University of Traditional Chinese Medicine affiliated Kaifeng hospital preparation roomprovides, medicine from hemp seed, oil, dried rehmannia root,rhubarb, Chinese angelic ca,peach kernel,the effect of raw Fructus aurantii Immaturus,licoric.root,Atractylodes processed after polishing pill prepared); control group: oral Maren soft capsule 3 grain Bid(Atwi J(Foshan) Pharmaceutical Co. Ltd., the country medicine accurate Z10930033).After 2 wee-ks of treatment, were observed before and after treatment in the patients of two groupsanaly-sis of TCM symptoms, fasting plasma glucose(FBG), 2 hour postprandial blood glucose(2h-BG), the changes of blood lipid and other related indicators, follow-up 2 months after drug withdrawal, and then understand the two groups of defecation, and to make statistical analysis.Results:(1) the total effective rate of treatment group was superior to the control group, the difference was significant(P< 0.05);(2)the TCM syndromes decreased significantly after treatment in the two groups aftertreatment, in the same group compared with those before treatment had significant difference.After the end of treatment between the two groups of TCM syndrome integral and significant difference(P< 0.05), and the treatment group was better than that of the control group.(3)the two groups after treatment FBG, 2h BG decreased significantly, in the same group aftertreatment compared with those before treatment had significant difference. The levels of FBG,2h BG after the end of treatment between the two groups decreased significantly, compared with the control group, there were significant or very significant difference(P<0.05, P<0.01).(4) the blood lipid levels were significantly decreased in the two groups after treatment, in the same group after treatment compared with those before treatment had significant difference.After the end of treatment between the two groups of blood lipid levels significantly decreased,compared with control group, the total cholesterol(TC), triglyceride(TG) had significantdecrease(P < 0.05), high density lipoprotein(HDL-C),low density lipoprotein(LDL-C)showed nostatistical significance(P>0. 05).(5)were followed up 2 months after drug withdrawal, the total effective rate of treatment groupwas superior to the control group, the difference was significant(P<0.05).(6)security analysis: treatment group and control group, blood, urine, stool, liver, kidney function, electr-ocardiogram changes of indexes had no statistical significance(P > 0.05), in the clinical course of treatment all patients had no adverse reaction and allergic phenomenon.Conclusion: hypoglycemic aperient pills may be effective in the treatment of diabetic constipation, significantly reduced diabetic constipation in patients with FBG, 2h BG, blood lipid indexes; significantly improve the clinical symptoms, and significantly compared with the control group(P<0.05), the advantage of safety indicators show hypoglycemic aperient p-illhas no obvious toxic side effect, curative effect.