| BackgroundHepatitis B cirrhosis(Liver cirrhosis) is one of the common diseases of liver diseases. Is liver function damage caused by a variety of factors of liver injury, all further development will experience a stage of liver cirrhosis, liver specific clinical manifestations as progressive,diffuse, fibrosis. From the perspective of histology and cytology with necrosis of liver cells, deformation,nodular regeneration, appear then compensatory proliferation of fibrous tissue and liver cells in the liver, liver blood circulation path and the structure of hepatic lobule [1],is gradually changing alternate repeat the above three kinds of changes of liver morphology results, finallytexture changes such as calcification, hardened results. Common such as viral hepatitis, fatty hepatitis, drug hepatitis, chemical hepatitis, alcoholic hepatitis, liver fluke, poisoning, toxic liver, liver metabolic liver disease caused by variouscomplex factors of the disease cause liver organic damage of [2], such as liver volumeshrinking or swelling, appear at the same time, fiber hyperplasia, liver diffuse lesions,calcification, harden or occupying change。After a lot of no clinical trials research proves, if early treatment of patients with liver cirrhosiscan be effectively system, there is hope for the disease control in the early compensatory period range, thereby delaying or even cirrhosis progress no longer even be reversed,because once the progression to cirrhosis to late when it indicates poor prognosis, critical condition when the endanger patients the life safety of the [3], there will be many complications, including hepatorenal syndrome, hepatic encephalopathy, upper gastrointestinal hemorrhage, electrolyte disorders such as [4], even developed end stage liver disease(liver failure or liver cancer) and end the lives of patients. Therefore, early diagnosis, early treatment, active prevention and the treatment of cirrhosis of the liver is particularly important that the prognosis of [5]. Conventional treatment of hepatitis B cirrhosis including general treatment: the evaluation of patients with liver function, if good liver function, should be appropriate to control the amount of activity, avoid too tired, if theliver dysfunction and worsen, should be absolute bed rest, the prohibition of physical labor, toprevent further deterioration of liver [6]; to promote the high calorie high protein, vitamin rich and delicious food is appropriate; as for drug therapy, at present by the liver and symptomatic and supportive treatment, and there is no effective drugs can cure hepatitis B cirrhosis。Clinical go up to often use add vitamins and other nutritional support; glutathione, silybindrugs liver; nucleoside analogues(including lamivudine, adefovir, entecavir etc.) antivirusthree major treatment means. The treatment method although can achieve a certain effect,but only in part or in the short term to alleviate the suffering of patients, and can not reverse liver fibrosis radically, so that pain fundamental lift.Liver cirrhosis is a traditional Chinese medicine, "product certificate" category. Motherlandmedicine this disease from the "heat toxin" theory, to explore the disease or because of heat toxin stagnation puzzled, damage and liver function, thus the emergence of a variety of clinical symptoms, mostly with the party selected drug treatment with cold medicine, but cold easilyhurt the human body healthy, although it has a temporary effect, but a long time with injured upright, is virtual difficult complex, but make the illness lingering. Clinicians after summing up calendar home theory and clinical experience, thought that the characteristics of pathogenesis as "liver stagnation and spleen deficiency blood stasis",according to the characteristics of the pathogenesis, develop treatment rule of soothing liver and invigorating spleen qi, blood stasis, removing blood stasis and liver softening Decoctionprescription. According to the clinical characteristics of the treatment of hepatitis B cirrhosis patients with compensated cirrhosis, for improving the clinical symptoms, liver function, blood routine, liverfiber four, gastrointestinal ultrasonography(courage spleen) has a certain effect, through the clinical verification, the side effects of smaller, has a positive effect on the prognosis of patients.In this study, the clinical symptoms and liver function of patients with decompensated liver cirrhosis as observation index, to investigate the clinical efficacy of Huayu soft liver soup, the correlation between the party and its clinical therapeutic effect and research from the aspects of pathogenesis of hepatitis B liver cirrhosis, provide a theoretical basis and reference for theapplication of traditional Chinese medicine clinical better treatment B liver cirrhosis, therebythe treatment of hepatitis B cirrhosis level to reach a higher level. And in addition to traditional detecting symptom score and laboratory blood indicators, but also by color Doppler ultrasound imaging to evaluate the curative effect and the condition of patients. ObjectiveLearning the classical theory of traditional Chinese medicine and the valuable experience of Chinese medicine treatment of liver cirrhosis, mining potential. Through clinical observation, to explore the clinical effect of removing blood stasis and liver softening Decoction in treatment of liver cirrhosis; through the research on the theoretical basis of Huayu Ruangan Decoction in the treatment of decompensated liver cirrhosis, to provide a reliable theoretical basis for the development and clinical application of removing blood stasis and soft liver soup. And to explore the diagnosis and therapeutic effect evaluation method of clinical liver cirrhosis. Methods80 patients who met the inclusion of decompensated liver cirrhosis standards, in accordance with the treatment time were randomly divided into stasis Ruangan decoction treatment groupand normal control group. Two groups of patients were given conventional protecting liver,reducing enzyme and jaundice, etiological treatment(antivirus, drinking, immune suppression)and other comprehensive treatment. The treatment group was given treatment based on syndrome differentiation give Huayu soft liver soup, 200ml/ time, 3 times / day, treatment for 6 months, observed for 6 months after the end of treatment. To make a scientific appraisal, the objective of the curative effect ofRuangan Decoction in the treatment of stasis cirrhosis。 ResultsAfter treatment the overall efficiency of 87.5% in the control group, the treatment group was 75%, the difference was statistically significant(P < 0.05); the treatment group in relieving clinical symptoms and improving liver function, liver fibrosis tests, blood coagulation index anddigestive tract super imaging indexes(diameter of portal vein, splenic vein diameter, length of the spleen) of each project scores were lower than the control group, the difference was statistically significant(P <0.05).ConclusionHuayu Ruangan decoction can improve the clinical symptoms of decompensated liver cirrhosis, liver function, hepatic fibrosis degree, for the clinical symptoms and quality of lifeafter the disease has significant effect. Even indexes in liver cirrhosis color Doppler imagingalso has certain effect, for the further development of the disease have to delay and preventaction, so as to improve the survival of patients after the disease for life. Embodies the traditional Chinese medicine symptoms, namely the disease development thought. |
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