Clinical Study Of Jianpihuatanfa Intervention In Prediabetes

ObjectTo use the method of jianpi huatan(Jianpi Huatan Decoction) to interfere the patients with phlegm-dampness due to deficiency of the spleen IGR. Its safety is evaluated and mechanism of action is explored after observing the clinical effect. MethodThe 60 IGR patients who meet the diagnostic criteria are randomly divided into traditional Chinese medicine group(n=30) and control group(n=30).Both of the groups are treated by diet control and sports,and the traditional Chinese medicine group is added with “Jianpi Huatan Decoction”, three times a day,take 250 ml after meals,with the course of 3 months, take telephone follow-up after one year. FPG,2h PG,Hb A1 c, FINS, BMI,lipid,liver and kidney function etc of each patient are detected before and after treatment. Evaluate its clinical efficacy and observe the safety by the indicators and changes in clinical symptoms. resultsAfter corresponding intervention groups were given three months, ①indicators medicine group(fasting blood glucose,2h postprandial blood glucose, glycated hemoglobin, fasting insulin, blood lipids, blood, etc.) were significantly improved compared with the control group change is not obvious, there was a significant difference compared with the control group; ② Chinese medicine group after treatment subjects eat less poor appetite, thirst not want to drink, bloating after eating, lassitude, loose stool, head and body weight difficulties, etc. clinical symptoms improved significantly compared with the previous integral control group declined despite the previous, but not statistically significant(P> 0.05); ③ compare aspects of TCM symptom score: total points over the previous TCM group were significantly different(P < 0.05), suggesting that the efficacy of traditional Chinese medicine group than the control group;④treatment after a comprehensive clinical efficacy: Chinese group 90% of the subjects treated effectively cured by 50% in the control group, 43.33% of the subject a therapeutically effective, effective Only 10 percent were Chinese medicine group were significantly better than basic intervention group; TCM group and the control group were not there ⑤ treatment after progression to diabetes subjects, after 83.33 percent of the subjects after intervention reversal of traditional Chinese medicine for life + normal glucose tolerance, the control group, only 36.67 percent reversal rate.No adverse reactions happen during treatment. A follow-up by telephone find the diabete conversion rate of traditional Chinese medicine group is significantly lower than the control group after one year. The traditional Chinese medicine group had progression of 6.67% of the subjects in the control group was 20% of the subjects of progression to diabetes. It prove traditional Chinese medicine treatment interventions to maintain normal glucose tolerance and slow disease progression in terms of relatively simple interventions have the advantage of living.There are significant differences between both groups was statistically significant(P <0.05). conclusionThe method of Jianpi Huatan can decrease the level of blood glucose and lipid, improve insulin resistance, relieve clinical symptoms, and effective in the treatment of IGR.The experiments also demonstrated the safety and efficacy of traditional Chinese medicine group in the treatment of IGR.