Analysis On Medication Rules Of Lierong Li For Treatment Of Dysfunctional Uterine Bleeding In Perimenopausal Based On Data Mining

Dysfunctional uterine bleeding in perimenopausal belongs to the Chinese traditional medicine′s metrorrhagia.It′s refers to women with irregular bleeding before and after menopause. The disease is common and multiple. My tutor professor Li divides the disease into bleeding period and bleeding from the interphase to treat. The clinical effect is remarkable. The subject aims to summarize her experience by data mining, further to provide the scientific basis for the traditional Chinese medicine treatment for dysfunctional uterine bleeding in perimenopausal.Objective The research by means of data mining,aims to preliminary discuss dysfunctional uterine bleeding in perimenopausal′s drug laws and analyze the characteristic of her speculations.Methods 30 cases of dysfunctional uterine bleeding in perimenopausal patients met the inclusion criteria were inputted in “TCM chuancheng fuzhu system” and analysis by means of rule analysis, improved mutual information, complex system entropy cluster and unsupervised hierarchical clustering entropy. All clinical dates would be divided into two groups according to bleeding, and dated mining total and levels in turn. thus discussing dysfunctional uterine bleeding in perimenopausal′s drug laws.Results The research through overall mining with levels respectively mining the selected 103 prescriptions.There were lots of results produce d in all and grouping prescriptions, including the frequency of drugs, as sociation rules between drugs, core portfolio and new prescriptions. Total ly ten drugs appear before the frequency are as follows:Shanyao、Moh anlian、Baishao、Nvzhenzi、Duanmuli、Xuduan、Shengdi、Gouqizi、Eji ao、Sangye.Bleeding period ten drugs are as follows:Mohanlian、Shanya o、Duanmuli、Baishao、Nvzhenzi、Ejiao、Sangye、Wuzeigu、Xueyutan、Xuanduan.Bleeding from the interphase period ten drugs are as follows:Shengdi、Shanyao、Baishao、Mohanlian、Xuduan、Nvhenzi、Huangbai、Gouqizi、Huangqi、Baizhu.The total medicine siqi are warming、cold and mild in major,the other two groups are following the same order r ank. Totally wuwei are sweet、bitter、sour and astringency flavor,mainl y focus on sweet and bitter. Comparing bleeding period with bleeding fr om the interphase period, the sour astringency drugs are used more ofte n, bleeding from the interphase period use sweet flavor drugs more. As to medicine guijing the top four are as follows: liver、kidney、spleen、l ung. Bleeding period use more drugs belong to lung jing, and bleeding from the interphase period drugs belong to heart exceed spleen rank fou r. In levels data mining, reducing the degree of support,there are grad ually emergence of a number of drugs.Bleeding period’s core drugs fun ctioned ziyin cold blood and stop bleeding, while bleeding from the inte rphase period drugs belong to liver、spleen、kidney and functioned notif y deficiency cold blood. Based on association rules a combination of co mmonly used drugs are:Shanyao-Mohanlian(-Duanmuli、Nvzhenzi、Baisha o、Ejiao、Sangye),Shanyao-Shengdi,Mohanlian-Shengdi(-Shanyao、Ba ishao、Nvzhenzi). New parts of the bleeding period are Huangbai-Shen gditan-Baishao-Diyutan-Mohanlian-Nvzhenzi-Sangye-Qianchaotan,Ejiao-Wu weizi-Shanyao-Duanmuli-Sanqimo-Huangqi-Xuduan-Wuzeigu. And new pa rts of bleeding from the interphase period are Xuduan-Tusizi-Huangqi-Sh anyao-Gouqizi,Shengdi-Maidong-Baishao-Mohanlian-Nvzhenzi,Digupi-Baizhu-Duanmuli-Huangbai-Wuweizi.Conclusion By data mining, we get that professor Li treat dysfunctional uterine bleeding in perimenopausal during bleeding period is focus on stop bleeding and clear heat, while bleeding from the interphase period is notify liver、spleen、kidney,Drug laws are difference in the same.It reflects the general rule and show the characteristic of personalized treatment at the same time.