The Clinical Research Of Treatment Of Flavored Siwu Decoction In Hanghighblood Pressure Of YinXvYangKang And The Mechanism Of Its Effect On CRP

Purpose:through clinical observation, observation flavored siwu decoction in the treatment of essential hypertension curative effect, and at the same time in the treatment, the risk factor to cause high blood pressure, plasma CRP whether have influence. By targeting flavored siwu decoction treating Yin deficiency type hand high blood pressure and the further research of the mechanism of its effect on CRP, explore flavored siwu decoction Yin YangKangHang the clinical effect of high blood pressure.Methods:our hospital inpatient and outpatient in accord with standard of high blood pressure, western medicine diagnosis and the syndrome of Yin deficiency and Yang after 60 cases, divided into treatment group 30 cases and control group 30 cases. According to the clinical research plan, according to the random, single blind, parallel group, positive medicine contrast principle. Treatment group using flavored siwu granules treatment, blunt, twice a day, a bag each time. The control group taking benzene sulfonic acid amlodipine piece 1 piece,1,1 times treatment.Two groups of a course of 6 weeks. Observe two groups of patients before and after treatment of blood pressure, CRP index changes and the changes of interleukin -6.8 weeks after the review, observation of 6 weeks after the treatment of blood pressure changes in treatment group, the control of blood pressure change, and the treatment group CRP index change and the change of interleukin -6. Observe whether antihypertensive effect and CRP index, and so on.Results:(1) blood pressure. Two groups of cases after six weeks after the treatment, the treatment group significant efficiency of 53.3%, the total effective rate was 90%; Control efficiency of 20%, the total effective rate was 56.7%. The total effective rate in treatment group than in control group (P<0.05). The two groups before and after treatment in patients with systolic blood pressure and diastolic blood pressure results is statistically significant (P<0.05). (2) the two groups of cases of CR. Two groups of cases after six weeks after treatment, after treatment of CRP are lower than before treatment. And the treatment group after treatment of numerical comparison shows that the treatment group of CRP are significantly lower than the control group, explain flavored siwu granules for Yin deficiency type hand has a certain effect in the treatment of high blood pressure, can reduce CRP. (3) safety evaluation. All cases during the period of treatment, adverse reactions to a total of 2 cases,1 case of abdominal pain, and 1 case of nausea, relation with drugs is not sure and do not make treatment to eliminate. The study of 60 cases of test results before and after treatment, blood, urine, kidney function, electrocardiogram (ecg) and no significant difference before and after therapy, explain flavored siwu granules curative effect in the treatment of Yin deficiency type hand hypertension security and stability.Conclusion:flavored siwu can effectively reduce blood pressure, according to Yin deficiency type hand hypertension have obvious curative effect, can effectively reduce the levels of serum CRP.