Correlation Analysis Of Cerebral Microbleeds Imaging Score And After Antiplatelet Therapy Cerebral Hemorrhage

objective: to study the relevance of(Cerebral Microbleeds, CMB) image score and the incidence of Cerebral hemorrhage, to provide forecast radiographic assessment of the risk of bleeding in the brain in patients of antiplatelet therapy with ischemic stroke of CMB. Methods: choice of acute Ischemic cerebrovascular disease of 12 months continuous hospital(including Transient Ischemic Attack TIA), patients with follow-up of 12 months. 4 weeks and 12 months as the two point observation after disease. Into group routine apply the craniocerebral Cmputed Tomography CT, Magnetic Resonance Imaging of MRI. Application of SPSS16.0 software package to analyze the results and related factors. Results: Having 172 cases of patients Conform to the set of conditions,among of 4 cases do not cooperate with, 2 cases of patients died, lost contact 7 cases in 12 months follow-up period were excluded, finally collected 159 cases of acute cerebral infarction patients, among them the CMB(+) group 82 cases, 77 cases of the CMB(-). Follow-up visit patients 21 cases(13.21%), telephone follow-up of 94 cases(59.12%), outpatient follow-up 44 cases(27.67%). Patients with baseline onditions : the CMB(+) group of average age(69.99 years) and the proportion of men(63.41%) were higher than that of the CMB(-) group, the difference was statistically significant(P < 0.05), suggesting the CMB(+) group older, male majority. CMB(+) group in patients with cerebral hemorrhage medical history(32.93%), significantly higher than the CMB(-) group was 6.49%, with significant difference(P < 0.01). CMB(+) group of proportion in cognitive function in patients higher than the CMB(-) group, the score values mean below the CMB(-) group, the difference had obvious statistical significance(P < 0.01). And high blood pressure, diabetes, hyperlipidemia, smoking atrial fibrillation and no obvious difference between the two groups(P > 0.05).CMB(+) group, 1 case of basal ganglia hemorrhage occurred after 5 months, the patient has a history of high blood pressure, cerebral hemorrhage history, cerebral hemorrhage has not been founded the CMB group(-), suggest with or without the CMB in patients of acute ischemic stroke, according to the guideline for formal antiplatelet therapy, less risk of cerebral hemorrhage in 12 months. Cerebral infarction patients with baseline comparison between Bleeding history and no history of bleeding: the history of hyperlipidemia in bleeding group was 62.50%, significantly higher than without a history of bleeding in the group of 35.43%, with significant difference(P < 0.01), cognitive function, CMB(+) in the history of bleeding group accounted for 75.00% and 84.38% respectively, higher than there is no history of bleeding were 51.18%, 43.31%, comparing differences between two groups is significant(P < 0.01). And age, gender, hypertension, diabetes, atrial fibrillation, and smoking has no obvious difference between the two groups(P > 0.05), cerebral infarction has a history of bleeding associated with hyperlipidemia, impaired cognition. CMB severity(NSL score) : no history of bleeding group: low, moderate and high risk accounts for 14.54%, 63.64%, 14.54% respectively, and history of bleeding in the group: low, moderate and high-risk were accounted for about 3.70%, 3.70%, 55.56%, between the three groups, including comparison between high-risk groups have significant difference,(P < 0.01), prompted when the CMB(NSL score) at high risk of cerebral hemorrhage was significantly higher.CMB and risk severity compare with different age group(< 60 years old, 60 or less < 80, ≥ 80- year- old 0f three age groups) : the CMB(NSL score) results showed that the risk at the age of 60 < 80, 80 or more or less two sets of scores between the moderate and high risk when compared with statistical significance(P < 0.05), indicating the degree of danger of CMB increased with age. Conclusion: the existence of the CMB is associated with age, sex and past history of bleeding in the brain. As the growth of the age, the greater the risk for CNB but cerebral hemorrhage patients has not been found. a lower risk of cerebral hemorrhage accompanied by CMB in patients with acute ischemic stroke antiplatelet therapy according to the current guidelines in 12 months. but need to further extend observation period in order to understand the long-term risks. CMB severity associated with age with history of bleeding in patients with cerebral infarction, prompts for taking antiplatelet agents should be measured with a history of bleeding in the brain of cerebral infarction patients has a history of bleeding associated with hyperlipidemia, cognitive impairment, but its clinical significance remains to be further research.