Study Of Benign Infantile Convulsions With Mild Gastroenteritis T Cell Activation And Cell Factor

Objective:To explore the action of immune function in benign infantile convulsions with mild gastroenteritis (BICE) pathogenesis by detecting the T cell activation and cell factor of BICE.Method:31infant patients with BICE hospitalized in the wards of department of neurology of The Children’s Hospital Zhejiang University School of Medicine from April2012to April2014were selected as the experiment group, while another23healthy infants accepting physical check in the same period were selected as the control group. Flow cytometry detection by BICE group acute stage, recovery and control group in peripheral blood levels of CD25+/CD3+CD4+, CD69+/CD3+CD4+, HLA-DR+/CD3+CD4+, CD25+/CD3+CD8+, CD69+/CD3+CD8+, HLA-DR+/CD3+CD8+, and IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ. Results:The peripheral blood HLA-DR+/CD3+CD4+, HLA-DR+/CD3+CD8+expression levels (7.300%±2.725%,29.560%±4.079%) of the acute phase of case group were higher than those of the control group(5.560±3.310%,19.730±12.639%),(t=2.110,2.649, P=0.040,0.011); the expression level of the peripheral blood IL-10was8.100(5.800-19.700) pg/ml, which was significantly higher than that of the control group[4.00(3.60-7.40) pg/ml],(z=-3.342, P=0.001).The peripheral blood HLA-DR+/CD3+CD4+, HLA-DR+/CD3+CD8+expression levels (7.140±2.179%、28.220±1.761%) in recovery were higher than the control group (t=2.108,2.543; P=0.04,0.014), which had no significant difference with acute stage(t=0.431,1.436; P=0.431,0161).The peripheral blood IL-10expression level was6.90(5.20-12.9) pg/ml in recovery was still higher than the control group(Z=-2.529, P=0.011), but lower than the acute stage (Z=-3.936, P=0.006).Conclusion:1.There is certain degree of immune dysfunction in BICE patients. T cell activation subgroup and the cell factor may participate in the morbidity progress of BICE.2. As an improvement, immune dysfunction is correct. IL-10can be used as a relatively sensitive marker for evaluating of the prognosis of BICE patients.