The Effect Of Conditional Stimulus Block On The Expected Vomiting In Children With Osteosarcoma Chemotherapy

Objective:1.To investigate the effect of conditional stimulus block on the expected vomiting in children with osteosarcoma chemotherapy.2. Provide further evidence for the etiology of vomiting.Methods:A review of a large number of relevant literature, specifically the incidence of pediatric patients with osteosarcoma expected nausea and vomiting and its impact on patient treatment; reason expected vomiting as well as analysis of the effectiveness of current interventions.To investigate the specific operation of the conditioned stimulation block therapy by pre investigation. To February2012-March2013during my children’s hospital osteosarcoma expected vomiting occurred in90patients pre-investigation, vomiting extent Ⅱ degrees24children and their guardians visitors in-depth interviews, clearly apparent cause vomiting expected to stimulate the type of conditions to determine the specific operating conditions to stimulate content blocking therapy. That is conditioned stimulus by cutting block therapy "chemotherapy" signal and all information associated with chemotherapy and other conditions of stimulation to reduce stimulus pairing these conditions and chemotherapy itself this unconditioned stimulus, reducing the formation of conditioned reflex, so to achieve the patient is expected to reduce the incidence of vomiting a way purposes.Conditional stimulus block therapy, in April2013-March2014period selected osteosarcoma patients aged6to14years old, there is expected to vomiting during the second cycle of chemotherapy, patients guardian consent, articulated and osteosarcoma in children. Randomized in the third cycle of chemotherapy when children were divided into observation group and control group. The control group care routine in the24hours prior to each use chemotherapy and four hours before the day of chemotherapy drugs on children and their guardians missionary before treatment, a detailed explanation of the chemotherapy drug name, time of use, possible side effects and response measures in order to work together to successfully complete the entire cycle of chemotherapy; observation group condition at each block therapy to stimulate the use of chemotherapy drugs that block the use of chemotherapy for children with all cases of chemotherapy-related information, but for children Press guardian care routine in24hours prior to each use chemotherapy and day4hours before using chemotherapy before treatment missionary. Comparison of two groups of children expected incidence of vomiting, vomiting extent. Then, the two groups of children in the use of chemotherapy drugs the day before chemotherapy lOmin blood, serum potassium concentration measured to compare the incidence and degree of occurrence of two groups of children hypokalemia. After the chemotherapy cycle, because they can not tolerate two statistics vomiting and hypokalemia and delays and interruptions chemotherapy cases.Using SPSS19.0statistical software for statistical analysis, χ2CMH test is used for comparison of rank count data, P<0.05was considered statistically significant.Analyzed conditioned stimulus block therapy of osteosarcoma chemotherapy on children with expected vomiting. Results:1. Applications conditioned stimulus block therapy can expect significantly decreased the incidence of expected vomiting, vomiting extent improved significantly. Observation group and control group expectedvomiting rates were22.6%and76.2%, a significant improvement in the degree of vomiting, degree Ⅲ incidence of vomiting was2.4%and16.7%respectively, the difference was statistically significant (P<0.05).2. Application conditioned stimulus block therapy to reduce the lead to vomiting due to the expected incidence of hypokalemia and low blood potassium level was also significantly reduced. Observation group and the control group the incidence of hypokalemia was15.5%and41.7%respectively, the difference was statistically significant; low potassium level have significantly reduced the observation group and the control group serum potassium<2.5mmol/L, respectively incidence1.2%and9.5%, the difference was statistically significant. Because we can not tolerate vomiting and hypokalemia and delays and interruptions chemotherapy group were observed in two cases, and0cases in the control group were14cases and3cases.Conclusion:Application conditioned stimulus block therapy, can significantly reduce children with osteosarcoma chemotherapy expected incidence of vomiting, reduced vomiting extent that time and the amount of chemotherapy is completed, to improve the quality of life of children with osteosarcoma.