Analysis Of Clinical Efficacy Of Prostaglandin E1in Treatment Of Patients With Acute Pancreatitis

Objective:Observe and record the acute pancreatitis patients having abdominalpain, nausea and vomiting, symptoms such as difficulty breathing. Design:randomized controlled experiment, the experimental group application ofprostaglandin E1this medicine, while the control group does not use thismedicine. The purpose is compared two groups of patients with clinicalsymptoms disappeared time to, amylase, serum lipase, high sensitive Creactive protein and procalcitonin (PCT) to the normal time. Providephysical therapy basis for treatment of guiding the clinical therapy ofacute pancreatitis.Materials and methods:In80cases (male52cases, female28cases) of patients with mild tomoderate acute pancreatitis, the average age of the experimental group(49.61+19.17) years old, the average age of the control group was(52.14+15.59) years old. The diagnostic criteria of AP: clinical meet twoto three features in the diagnosis of AP.(1) in accordance with AP (acute,sudden abdominal pain, persistent, severe abdominal pain, often to theback diffusion);(2) the levels of serum amylase and lipase activity (or) at>3times the upper limit of normal value;(3) enhanced CT/MRI or ultrasound imaging changes were AP. Grading diagnosis of pancreatitisinclude mild AP (mild acute pancreatitis, MAP), moderate AP(moderately severe acute pancreatitis, MSAP) and severe AP (severeacute pancreatitis, SAP). The research object of this experiment is inpatients with mild to moderate acute pancreatitis, are required to meet thefollowing admission criteria and exclusion criteria. Inclusion criteria:(1)met the diagnostic criteria of acute pancreatitis;(2) over18years of age.Exclusion criteria:(1) on prostaglandin drug allergy;(2) pregnant andlactation period;(3) complicated with serious heart, lung, liver, kidney,blood, immune diseases and mental illness;(4) due to trauma, surgery,and the tumor induced by ERCP/ES;(5) admission before has usedprostaglandin preparations;(6) there is a history of glaucoma orintraocular pressure is too high. The experimental group application ofprostaglandin E1in control group did not use the drug.Control group: treated with drug treatment, fasting, monitoring vitalsigns, pain, gastrointestinal decompression, intravenous fluids to maintainwater, electrolyte balance; intravenous nutrition: vitamin, amino acid,glutamine; antibiotics to prevent bacterial infection; acid suppression,suppression, reduction of pancreatic secretion. Experimental group: Onthe basis of the treatment of the control group，admission diagnosisimmediately after the administration of prostaglandin E1, trade nameKaishi (Beijing Taide pharmaceutical),10ug/d, adding0.9%Sodium Chloride Solution100ml intravenous injection. The two groups wereobserved and compared the serum amylase, lipase, C-reactive protein(CRP),procalcitonin(PCT),the changes of amylase.Result:The experimental group and the control group, serum amylase, Creactive protein and neutrophil recovery time had significant difference,the experimental group returned to normal time is shorter than the controlgroup. Urine amylase, lipase, PTC and white cell recovery of normal timedifference between the two groups had no statistical significance. Theaverage hospitalization days in experimental group was less than that ofthe control group and the number of hospitalization expenses, theexperimental group was significantly lower than that of control group.Prostaglandin E1can effectively improve the recovery process of acutepancreatitis.Conclusion:Prostaglandin E1can improve pancreatic microcirculation, inhibitionof platelet aggregation and platelet thromboxane A2synthesis, at thesame time, PGE1can inhibit a variety of endogenously stimulatedpancreatic secretion function, protect the cell and organelle stability,prevent pancreatic soluble several digestive enzymes in vivo enzymerelease, dissolved prevent pancreatic lysosomal damage. There is apositive role in the development and effective control of the disease, the hospitalization time and cost, abdominal pain relief time, blood amylase,C reactive protein and white blood cell count dropped to normal time wasobviously shorter.