Clinical Study Of The Relationship Between The Body Mass Index (BMI) And The Clinical Effect Of Sodium Hyaluronate Injected Into Patients With Knee Osteoarthritis

Objective:This paper has reported the clinical outcome of sodium hyaluronate used in patients with knee osteoarthritis. Researchers analyzed the relationship between the body mass index (BMI) and the clinical effect of sodium hyaluronate, in order to lay the foundation for the Traditional Chinese Medicine to prevent and treat this kind of disease.Method:This retrospective study had adopted patients with knee osteoarthritis who were treated with intra-articular injection of sodium hyaluronate in Hospital of Chengdu university of Traditional Chinese Medicine from January2012to March2014. Patients’age, gender, BMI, WOMAC score were included as the evaluation standard. Researchers aimed to find out the relationship between BMI and the clinical outcome, and its relativity with time.Result:1.59%(119/200) of the patients has normal weight,34%(68/200) of the patients were overweight and7%(13/200) of the patients belonged to obese. There was no statistically significant difference in the distribution of age stage (P=0.175) or gender (P=0.536) in different subgroup of weight.2.68%(136/200) of the patients were female, the other32%(64/200) of the patients were male. There was no significant relationship between gender and the treatment outcome (P=0.813)3. The WOMAC score were adopted to evaluate the treatment outcome. The efficacy of treatment were evaluated as the difference of score between a specific time point and the initially score before evaluation. The results were summarized as follows:(1)The WOMAC scores were improved more or less after the treatment of sodium hyaluronate. The most effective pesticide effect lasts about12weeks’ time.The treatment effect came to reduce after12weeks, with the rising of the (2)After5weeks’treatment,53%(108/200) of the patients got significant effective outcome,33%(65/200) of the patients got effective outcome,10%(20/200) of the patients were cured and4%(7/200)of the patients didn’t get and improve. Body mass index had negative correlation with the clinical outcome (r=-0.96, P=0.007).(3)The BMI had negative correlation with clinical outcome at8weeks’ follow-up (r=-0.95, P=0.004).(4)The BMI had negative correlation with clinical outcome at12weeks’ follow-up (r=-0.78, P=0.003).(5)There were no significant correlation between BMI and clinical outcome after6months’follow-up (r=-0.36, P=0.169).(6)There were no significant correlation between BMI and clinical outcome after1year’s follow-up (r=-0.23, P=0.143).Conclusion:1.The treatment by Intra-articular injection of sodium hyaluronate was effective for patients with mild and moderate knee osteoarthritis in improving the function of knee, and as a result improve the life equality. On the other hand, the pesticide effect is hard to last for long, which provides a new angle for traditional Chinese medicine to take part in the intervention.2.The BMI had negative correlation with clinical outcome during the period of the pesticide effect lasts. The higher the BMI, the poor the treatment outcome. So intervention should be used to get lower BMI in order to get better treatment outcome.3.Female were more common than male in knee osteoarthritis, but there were no relationship between gender and the treatment outcome.