Single Intra-articular Injection Of Sodium Hyaluronate Versus Intra-articular Injection Of Sodium Hyaluronate Combined With Oral Lucosamine,an Analysis Of Therapeutic Effct To Knee Osteoarthritis

Objective:Single intra-articular injection of sodium hyaluronate under the guidance of ultrasound versus intra-articular injection of sodium hyaluronate under the guidance of ultrasound combined with oral glucosamine,an analysis of therapeutic effct to knee osteoarthritis.Methods:100patients of Knee Osteoarthritis was assigned into two groups randomly and double-blindly. Both groups accepted Sodium hyaluronate injected into articular cavity and took glucosamine hydrochioride or placebo separately. We evaluated patients’condition by WOMAC index and recorded synovial thickness and effusion depth of knee joint as while as cartilaginous thickness on lateral femoral epicondyle by ultrasound before,3weeks and9weeks after the beginning of the trial.Results:ln control group, synovial thickness, effusion depth and WOMAC score at the end of3rd week didn’t show significant difference to those before treatment(p>0.05), while those in experimental group show statistical difference (p<0.05). Following-up for9weeks, synovial thickness, effusion depth and WOMAC score of two groups showed statistical difference (p<0.05), while the cartilaginous thickness didn’t show obvious difference no matter treated for3or9weeks (p>0.05). Recorded at the end of the third week, synovial thickness, effusion depth and WOMAC score of experimental group showed statistical advantage to those in control group (p<0.05), while the cartilaginous thickness didn’t show such advantage (p>0.05). there were no significant difference on synovial thickness, effusion depth and WOMAC between two groups after9weeks following-up.Conclusion:To treat knee osteoarthritis, Sodium hyaluronate injected into articular cavity can improve clinical symptom obviously, but not to the cartilaginous thickness. The symptom would improved faster combining glucosamine hydrochioride po.