| ObjectiveAnalyse the clinicopathologic characteristics and prognostic factors of165cases of Ⅰ al-Ⅱ a2stage adenocarcima of the uterine cervix (AC).Methods165cases of cervical adenocarcinoma that undergone radical hysterectomy were diagnosed in Zhejiang University Women’s hospital from2003.06to2013.06. Characteristics incluging age, first time sex age, numbers of pregnancy, histological type, tumor markers, grade of differentiation, biggest line of tumor, resection margin, lymph-vascular space invasion(LVSI),lymph node metastasis, parametrium invasion(PI), ovarian metastasis, neoadjuvant chemotherapy(NACT), postoperative adjuvant therapy, state of recurrence and survival were collected. Then we investigated the probable prognostic factors by the means of univiariate and multivariate analysis.ResultThe5-year overall survival(OS) and5-year recurrence-free survival rate (RFS) were89.5%,88.9%respectively. Age,stage,grade of differentiation, lymph node metastasis,deep stromal infiltration, ovarian metastasis and postoperative adjuvant therapy were significant for RFS in univiariate analysis. For OS, grade of differentiation, lymph node metastasis,deep stromal infiltration,ovarian metastasis and postoperative adjuvant therapy were significant. Multiviariate analysis implied that ovarian metastasis and postoperative adjuvant therapy were common prognostic factors for OS and DFS, grade of differentiation was an another prognostic faotor for RFS.ConclusionRROvarian metastasis, postoperative adjuvant therapy and grade of differentiation were signicant for RFS. Both ovarian metastasis and postoperative adjuvant therapy affected OS for Ⅰ al-Ⅱ a2stage cervical adenocarcinoma. Radical hysteractermy was the optimal treatment for early stage adenocarcinoma of the uterine cervix. Ovarian preservation was feasible during the operation. The better postoperative treatment was radiotherapy for the cervical adenocarcinoma wih high risk factors. |
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