Study On The Risk Factors Of Metabolic Syndrome And Correlation Between Metabolic Syndrome And Fibrinogen Among The Urban Health Check-up Crowd In China

ObjectivesTo understand the prevalence of metabolic syndrome (MS) among health check-up population in urban China; to explore main risk factors of developing scientific policy and intervention for prevention and control MS. Meanwhile, the research aimed to discover the correlation between different levels of fibrinogen and MS to find new markers for the diagnosis and treatment of MS.Methods6589individuals whose information was complete were analyzed based on the healthy check-up center database in Shandong province among urban population from2006to2008. According to diagnosis standard recommended by Chinese Diabetes Society, Chinese Medical Association in2004, all samples were diagnosed as MS and non-MS. SAS9.2and Excel software were used for statistical analysis; descriptive statistical analysis includs mean, standard deviation and prevalence, and the inferential statistical analysis such as t test, Student-Newman-Keuls (SNK) test and Chi-square test were applied. The binary classification Logistic regression were used to explore multiple factors analysis of MS; P<0.05mean the difference was statistically significant.Results1. Background of the research samples6589individuals were included in this survey, among them men accounted for77.74%(5122) and women were22.26%(1467);3.81%was30years old and under, 19.64%was30～40years old,40～50years old was39.70%,1586people (24.07%) was50-60years old, and842(12.78%) people was over60years old group.2. The prevalence of MS1454people had metabolic syndrome. The prevalence of metabolic syndrome was22.07%;25.60%of men and9.75%of women had the disease. The difference between male and female was statistically significant (P<0.001). The lowest prevalence was6.37%among people under the age of30; while the highest group was more than60years old group which was up to26.60%. The prevalence difference was statistically significant among all age groups. As for as male, the prevalence (30.74%) among50-60age group was highest; For female, the prevalence became more and more higher with age, and the highest was28.32%among groups of upper60years. Among different sub-types of MS, the prevalence rate of Obesity was21.22%; the prevalence rate of High blood pressure was10.38%, and Hypertension was15.48%; High TG hematic disease was19.50%and Low HDL-C disease was2.70%.3. The prevalence of different types of MSAccording to components, MS can be divided into five different types:type Ⅰ is obese or overweight, high blood pressure and blood sugar; type Ⅱ stands for obese or overweight, high blood sugar and blood fat abnormality; type Ⅲ is hypertension, hyperglycemia and dyslipidemia; type Ⅳ is obese or overweight, hypertension and dyslipidemia, and type Ⅴ is obese or overweight, high blood pressure, blood sugar and dyslipidemia. Among of them, the prevalence of Type I was11.41%; the lowest is type Ⅴ(1.15%).4. Single factor analysis resultsThe prevalence of MS among smokers was24.80%. It was higher than that of non-smokers (15.52%); this difference was statistically significant (P<0.001). The prevalence of drinkers was25.61%,; it was higher than that of nondrinkers (19.69%). The difference between drinkers and nondrinkers was statistically significant (P<0.001). According to the number of days in a week, during which sleeping time is more than7hours, the sample population was divided into five groups:0days,1～2days,3～4days,5～6days and7days. The prevalence of MS was24.33%,23.88%,20.45%,21.83%,20.45%respectively. The difference among these groups was statistically significant (P<0.05). According to the daily time of practice, the samples were divided into:less than1hour,1～2hours and more than2hours. The prevalence of MS was25.00%,21.99%and22.18%accordingly. There was no statistically significant difference (χ2=0.172, P>0.172).5. Multi-factor analysis resultsSmoking is the risk factor of MS.The probability of occurrence of MS among smokers was1.372times higher than nonsmokers; MS risk in men was1.667times higher than women; old age group was the higher risk age of the metabolic syndrome,especially50years old and upwards.6. The relationship between fibrinogen and MSAccording to the level of fibrinogen from low to high based on quartile method, the research population was divided into four groups A, B, C, D. The prevalence of MS was respectively;20.47%,19.26%,22.99%,19.26%. The difference for prevalence of MS between different groups was statistically significant (P<0.01). Cochran-Armitage trend test showed that with the increase of fibrinogen, prevalence of MS was on the rise. The result showed that the fibrinogen levels were significantly higher than that of controls group.7. The correlation between Fibrinogen and sub-type of MSMulti-factor Logistic regression analysis results showed that with the increase of fibrinogen, the incidence of the MS among physical examination population decreased for man.Conclusions1. The prevalence of MS among health check-up population in urban areas was lower than that in the developed countries; but higher than that in the south China urban and those in previous years. Meanwhile, the prevalence of MS increased with age.2. Among different sub-type of MS, the obesity group had the highest prevalence, followed by high TG Hematic disease, high blood pressure, and high blood sugar.3. Among different sub-type of MS, the incidence of MS among population who suffered from obese or overweigh, hypertension and hyperglycemia simultaneously was highest, while those who had obese or overweight and high blood pressure, high blood sugar and blood fat disorder has the lowest incidence. As far as constituent ratio, those with obese or overweigh, hypertension and hyperglycemia had the highest proportion. The second place was those with obese or overweight, high blood sugar and blood fat disorder.4. The population who smoked, drinked and was lack of sleeping had a higher risk to suffer from MS. Those who exercised everyday had a lower incidence rate of MS in any sub-type.5. Man, elder and smoker were the high risk group resulted in MS.6. The prevalence of MS became higher in higher plasma fibrinogen level group. Case group had significantly higher risk than control group.7. With the lever of plasma FIB increased for man, the risk for MS increased. The low FIB might be the factor to MS prevent.