Epidemiological Analysis Of Second Trimester Prenatal Screening And Diagnosis In Zaozhuang,2011-2013

Objective:Objective:Based on the retrospective analysis of clinical data of Zaozhuang area by the second trimester prenatal screening and prenatal diagnosis, with the purpose of exploring the optimal time for second trimester prenatal screening, and selecting appropriate means of prenatal diagnosis to reduce birth defects and improve the quality of the newborn population. Methods:There were18287pregnant women in Zaozhuang area who were at15-20+6weeks of pregnancy attended this research from2011to2013.Serum AFP, Free-β HCG and uE3were detected in the examination. Then we assessed the low, critical and high risk through the risk assessment software with age, gestational age, body weight and the other factors. The pregnant women those who were critical and high-risk could choose peripheral blood karyotype of analysis or amniotic karyotype analysis and four-dimensional ultrasound examination, according to the principle of voluntary,and then to terminate pregnancy who malformation diagnosed by inoculation on the pregnant women and to track the prenatal diagnosis of abnormal prenatal infant outcome. Results:(1) Prenatal diagnosis rate of high risk and critical risk from2011to2013were5.33%,5.62%,5.74%and4.84%,5.01%,5.16%,which were compared with the domestic reports in the literature of second trimester prenatal screening of high risk rate5.67%and critical risk5.05%,there was no significant difference;the high risk of neural tube defect screening was in agree with the reported in the literature,but there is increasing year by year.(2)15-16+6weeks pregnant and prenatal screening for 19-20+6weeks in high risk and critical risk rate compared with the literature screening rate showed no significant differences in literature (P>0.05).And at17-18+6weeks of prenatal screening of high risk and critical risk rate,there was a significant difference (P<0.05),when compared to the literature screening rate and prenatal screening for15-16+6weeks and19-20+6weeks of high risk and critical risk rate.(3)A comparative analysis of chromosome karyotype of amniotic fluid invasive and noninvasive peripheral blood karyotype showed no significant difference in diagnosis rate (P>0.05),no peripheral blood karyotype and abnormal chromosome analysis of amniotic fluid puncture by karyotype analysis were abnormal.(4)Prenatal screening low-risk and prenatal diagnosis of fetal malformation who were exclued on tracing pregnancy and perinatal outcome,pregnancy outcomes were good,no oaf was born. Conclusion:The propaganda should be strengthened,prenatal screening and prenatal diagnosis should be popularized,choosing the best time for prenatal screening,minimizing the malformation,choosing no peripheral blood karyotype analysis and does not affecting the accuracy of diagnosis of malformations of infants.With the measures took, pregnant women and their families were more willing to accept the research. In conclusion,it had the vital significance to strengthen the prevention and control of birth defects and improve the quality of the population.