Investigation Of Various Prenatal Diagnostic Techniques Applying In Control Of Birth Defects

Birth defects(BD)refers to the existing abnormality of form,function,biochemistry,and spirit when the infant leaves the mother's body,which has become one of the main causes of infant death,disability in children and adults in the world.In 2001,China began to implement the birth defect intervention project,and established a three-level prevention and control system with primary intervention as the main body,secondary intervention as the key,and tertiary intervention as the supplement.Primary prevention is the prevention of birth defects,including pre-marital examination,genetic counseling,and so on;secondary prevention refers to the reduction of birth defects,mainly by early detection,early diagnosis and early adoption in pregnancy to prevent birth defects,so prenatal diagnosis and prenatal screening are particularly important;tertiary prevention is the treatment after the birth of a defective child.Prenatal screening and prenatal diagnosis belong to the secondary intervention,which can effectively prevent birth defects and reduce the burden on family and society.Taking the 21-trisomy syndrome as an example,the economic burden of the family and the society will be increased by about 600,000 per case at the present economic level.At the same time,the higher the mother's age,the higher the probability of occurrence.In the special period of two child,the secondary prevention work faces serious challenges.Objective To implement thoroughly the “healthy china 2030” program raise by The state council of the party,to understand and analyze prenatal screening and prenatal diagnosis in Qingdao,and to provide a scientific basis for the intervention of birth defects,the prenatal screening and prenatal diagnosis in Qingdao from 2014 to 2016 were retrospectively analyzed.Method Biochemical values of the serum markers(AFP?free-?-HCG??E3)of pregnant women were measured used by 1235 Automatic Immunoassay System.At the same time,combined with its conduct the risk assessment of pregnancy age,weight and other factors,recall the pregnant women who are at high risk or critical risk,and suggest follow-up amniotic fluid detection or non-invasive DNA testing and imaging detection,closely followed up until the second half of the year.Results Among the 327,788 pregnant women who received prenatal screening,the high-risk are 19025 cases(5.8%),of which 16,384 cases received non-invasive DNA testing,and 5472 cases received the amniotic fluid prenatal diagnosis,381 cases of abnormal cases were detected.The difference of abnormal detection rate is statistically significant.Conclusion As the two-child policy open,the number of older pregnant women is increasing.The subsequent prenatal testing pressure,high-throughput sequencing of all people on noninvasive DNA or amniotic fluid prenatal diagnosis is obviously unrealisti.Implements the serological screening joint noninvasive DNA,amniotic fluid,prenatal diagnosis,ultrasonic testing step by step screening model corresponds to the current national conditions of our country.