Quantitative Analysis Of Documents About Traditional Chinese Medicine Treatment To CVA And System Evaluation Of Its RCT

Objective：1. It is reflected which are situation and trend of traditional Chinese medicinetreatment of cough variant asthma in the latest10years in China, for providing referencebasis for further studying on the clinical treatment of cough variant asthma.2. Summarize traditional Chinese medicine and regulation used to remedy coughvariant asthma, giving physician dialectical thinking and choosing drugs of curing coughvariant asthma.3. It is assessed that randomized controlled trial of traditional Chinese medicinetreatment of cough variant asthma, to understand the quality of the literature.4. It is evaluated that clinical curative effect and safety of randomized controlled trialof traditional Chinese medicine remedy cough variant asthma, to provide clinical makingdecision reliable reference data.Methods：1. Retrieve documents of traditional Chinese medicine treatment of cough variantasthma in database such as CNKI VIP Wanfang in January2004-December2013,analyzing frequency with the method of literature computation analysis about literaturetype, year distribution, region distribution and author organization published papers ofnumber, periodical distribution, and frequency statistics.2. Record all Chinese medicine in literature about treatment of cough variant asthma,which are in the study1, count every medicine frequence, and then classify the top40medicines according to function, summing up rules of curing cough variant asthmareversely.3. Develop a standard of evaluation by the CONSORT statement, literature of TCMtherapeutic systemic evaluation and information quality evaluation, as well as the reportsof the related literature, and then assess the collecting literature quality of the randomizedcontrolled trials in study1according to the standard.4. Select the literature by clinical effect and recurrence rate of outcome indicator instudy2, and then apply Meta analysis of approach to explain outcomes, as well assensitivity analysis, publication bias analysis. Results：1. There are564articles included. From the year2004to2009, the tendency ofliterature quantity is increasing, and the year2009-2012, the one is basically stable; thoseof31.74%are published on many periodicals, such as Hebei Journal of Chinese Medicine,Sichuan Journal of Chinese Medicine, Shaanxi Journal of Chinese Medicine, GuangmingJournal of Chinese Medicine, Inner Mongolia Journal of Chinese Medicine, JournalJournal of New Chinese Medicine, Shanxi Journal of Chinese Medicine and so on. Thehigher percentage amount of provinces are distributed in Guangdong, Jiangsu, Shandong,Henan, Beijing, etc., and the companies are the Nanjing University of Chinese Medicine,China academy of Traditional Chinese Medicine Xiyuan Hospital, Beijing University ofChinese Medicine, Guangzhou University of Chinese Medicine, Hunan University ofChinese Medicine, etc. The type and share of literature that the clinical researchesaccounted for73%, reviews13%, theory8%, individuals of experience6%.2. There are339articles, in the total of564, containing232kinds Chinese medicine,involving21classes. Chinese medicines for the treatment of cough variant asthma, whichare used commonly, are ephedra, bitter almonds, dried tangerine or orange peel, cicada,earthworm, radix scutellariae, radix platycodi, pinellia, etc. The functions of medicinesmainly can expel phlegm with ceasing cough and asthma, drive the surface iniquities away,make deficiency better off, clear heat, balance the Qi, extinct wind by liver causing andconverge things which are impending loss from the body, etc.3. There are103articles about randomized controlled trial, which are included a totalof564, and all of that have inadequate design of methods report and low quality.4. There are18articles about contrasting traditional Chinese medicine with formaldrugs and15about contrasting traditional Chinese medicine combined with formal drugswith the formal drugs, which are included in Part3of103literatures, and theMeta-analysis results showed that the contrast have significant statistical deferences inclinical curative effects and the recurrence rate.Conclusion：1. A large number of literatures have been published, and most are lower levels. Thereis little difference among the distributed regions in literature quantities. The researchersconcentrated in universities or hospitals which have higher situation and more attention instudying, but they are partial to the more clinic and less theories and personality experiences. It needs increasing the higher quality articles, paying attention to the westernregion of scientific research situation, developing theory study and accumulating personalexperiences.2. According to the top40of the frequence of Chinese medicine and their effects,cough variant asthma is commonly charactered by the feeble body and powerful surfaceand principle entreated through facilitating positive Qi and removing pathogenesis.3. Randomized controlled trial of clinical studies are low levels. Corelated scientificresearchers have less attentions to scientific design methods. Hoping for elevating degreeto valuing the methods and standardizing the reports, aim to improve the literature.4. The curative effect of remedying cough variant asthma the only traditional Chinesemedicine or combination of Chinese and western medicine is superior to western medicine,but because of including the low quality of literature, the results should be treatedcautiously when making clinical decisions.