Meta Analysis Of The Effectiveness Of Traditional Chinese Medicine In The Treatment Of Children With Cough Variant Asthma Based On Data Mining

Purpose:1.A systematic evaluation of the efficacy of traditional Chinese medicine in the treatment of children’s cough variant asthma by the method of Meta analysis.2.The medication rule will be carried out through the TCM inheritance auxiliary platform,and data mining will be conducted on the prescriptions of children,and Director Hao Ruifang’s medication rule will be summarized in order to provide clinical reference and ideas.Method:1.Search the Chinese Journal Full-text Database(CNKI),China Journal Full-text Database(VIP),Wanfang Full-text Database and foreign language databases such as Pubmed,Embase,etc.,and collect all the literature of randomized controlled trials of traditional Chinese medicine in the treatment of children with cough variant asthma.Two researchers independently read and screened the literature according to the inclusion and exclusion criteria,and finally screened the literature that meets the requirements,extracted the data for Meta analysis,used the Cochrane risk bias assessment tool for quality evaluation,and used Review Manager 5.4 to evaluate the literature research results Statistical analysis of data.2.According to the diagnosis,inclusion and exclusion criteria,81 children with CVA admitted to Director Hao Ruifang’s outpatient clinic from September 2019 to January 2021 were screened and sorted out.The patient’s gender,age,Chinese medicine prescriptions and Chinese medicine dosages will be collected and entered into the traditional Chinese medicine inheritance auxiliary platform system(V2.5),and the software’s functions such as information statistics,association rules,and complex system entropy hierarchical clustering analysis will be used for prescriptions Data mining,and display the research results in the form of graphs and tables.Result:1.Meta analysis partAccording to the established inclusion and exclusion criteria,a total of 23 documents were selected that met the conditions,and the following results were obtained after analysis:(1)A total of 23 documents were included in this study,involving 1495 children,including751 cases in the traditional Chinese medicine group.There were 744 cases in the western medicine group.The overall quality of the included 23 studies is not high.Many studies report insufficient information and unknown risk assessments.There are statistical differences in the total clinical effectiveness,cough level,total IGE level,and recurrence rate between the traditional Chinese medicine group and the western medicine group.The comparison of PEF in lung function was not statistically significant.(2)The frequency statistics of Chinese medicines involved 91 Chinese medicines.A total of 30 drugs with a frequency of ≥100 times of medication,most of which are products for dispelling wind and evil,relieving spasms and relieving cough,replenishing qi and invigorating the spleen,clearing heat and removing phlegm,promoting blood circulation and removing blood stasis.Table drugs,liver-eliminating wind drugs,and heat-clearing drugs are commonly used by physicians for the treatment of children’s CVA.Statistics of traditional Chinese medicines indicate that drugs classified into the lung meridian are used most in this disease,followed by drugs that enter the spleen and liver meridian,indicating that this disease is related to the disease.Lung,spleen and liver are closely related.2.Part of the rule of medication(1)The etiology and pathogenesis of CVA: The pathogenesis of CVA is mainly in the lung,spleen and liver.The pathogenesis of CVA is exogenous wind pathogens,internal injury to the spleen and lungs,liver qi invades the lungs,leading to phlegm obstruction due to qi,and phlegm with qi,and qi Go up backwards,causing a cough.(2)Medication rule:According to the results of data mining,the prescription drugs are mainly warm and cold in the four qi;bitter drugs are used in the highest proportion of the five flavors;the main meridian of the drugs is the lung meridian,the spleen meridian and the liver meridian.After the second;high-frequency drugs show the distribution pattern of soothing wind and lungs,relieving spasm and relieving cough,strengthening spleen and eliminating phlegm.The frequency of medication reflects that CVA treats the lung,spleen and liver,and the main treatment is to calm the lung,promote the spleen and regulate the liver.The prescription information shows that Director Hao Ruifang treats children CVA from the lung,spleen,and liver.The prescription drugs are used in combination with cold and warm,attacking and supplementing,and playing the diagnosis and treatment ideas of dispelling wind and spasm,resolving phlegm and relieving cough.(3)Commonly used drug combinations: 132 commonly used drug combinations are summarized through the analysis of association rules.The first 10 groups are:(1)Licorice,almond;(2)Licorice,platycodon;(3)Platus platycodon,almond;(4)Licorice,platycodon,almond;(5)Scutellaria,licorice;(6)Scutellaria,almonds;(7)Scutellaria,platycodon;(8)Scutellaria,licorice,platycodon;(9)Scutellaria,licorice,almonds;(10)Scutellaria,platycodon,almonds..(4)Core drugs: licorice,almonds,platycodon,scutellaria,citrus aurantium,reed root,cicada slough,honey ephedra,perilla seed,aster,sternum,mulberry bark,coltsfoot flower.(5)Cluster prescription: Based on cluster analysis,five prescription combinations were obtained,which were: C1: Stemona,mimahuang,almond,aster,Baiqian,Platycodon grandiflorum,Schizonepeta tenuifolia,cicada slough,Bombyx Batryticatus,tangerine peel and licorice;C2: ephedra,almond,gypsum,honeysuckle,forsythia,reed root,Platycodon grandiflorum,cicada slough,earthworm and licorice;C3:ephedra,Scutellaria baicalensis,cortex mori,Trichosanthes,Fritillaria thunbergii,Poria cocos,Platycodon grandiflorum,Pericarpium Citri Reticulatae,Bombyx Batryticatus,earthworm and licorice;C4: ephedra,cortex mori,Scutellaria,almond,tusihua,Pinellia ternata,Perilla frutescens,Bombyx Batryticatus,earthworm,licorice;C5: Glehnia littoralis,Radix Saposhnikoviae,Radix Ophiopogonis,Fructus Mume,Fructus Schisandrae,mulberry leaf,polygonatum odoratum,licorice.Conclusion:1.Meta-analysis shows that Chinese medicine is more effective in treating children with cough variant asthma than the western medicine group,In view of the low quality of clinical research literature,there is a certain degree of publication bias,which needs to be further confirmed by high-quality research,or put forward a more appropriate evidence system of traditional Chinese medicine.2.The rule of medication: The results of this study reflect Director Hao Ruifang’s understanding of CVA.Through comprehensive analysis of data mining results,the disease location of CVA is mainly the lung,followed by the spleen and liver.The etiology and pathogenesis of CVA are external wind pathogens and internal injury to the spleen.Lung,liver qi invades the lungs,leading to phlegm obstruction due to qi,and phlegm following the gas flow,and the qi goes up backwards,causing coughing.The medication rule reflects the treatment of children’s CVA from lung,spleen,and liver.The prescription drugs are used in combination with cold and warm,attacking and supplementing,and they play the diagnosis and treatment ideas of dispelling wind and relieving spasm,resolving phlegm and relieving cough;commonly used drug combinations reflect wind and spasm relieving The combination law of simultaneous use,relieving cough and resolving phlegm.The core drugs are mainly to sooth wind and lungs,relieve spasm and relieve cough,invigorate the spleen and resolve phlegm;the new entropy clustering cube starts from different perspectives and etiology and pathogenesis,and the effect remains to be clinical Verify in practice.