Meta-analysis Of Qufeng Method Therapy For Cough Variant Asthma

Objective To evaluate objectively the efficacy and safety of Qufeng method in treating cough variant asthma by systematic evaluation.Methods According to the systematic evaluation method required by the definition of Cochrane Collaborative Network,a search strategy was formulated to retrieve randomized controlled trials(RCT)of expelling wind therapy for cough variant asthma.Electronic search included CNKI full-text database of China HowNet,Weipu Chinese scientific and Technological Journal database,Chinese biomedical literature database and Wanfang database.Qualifications were screened according to inclusion and exclusion criteria.Documents are then evaluated and valid data are extracted.Meta-analysis is performed using RevMan 5.3 software.Results A total of 1191 assessable patients with cough variant asthma participated in13 studies,all of which had a high risk of bias.The results of meta-analysis showed that compared with the western medicine group,the method of expelling wind was superior to the western medicine group in improving the total effective rate(heterogeneity test showed that(P=0.64,I~2=0%;OR=2.97,95%CI[2.05,4.31],and Z=5.75,P<0.00001).Compared with the western medicine group,the method of expelling wind could improve the cough variant asthma.The curative effect of cough variant asthma in Qufeng plus Western medicine group(P=0.99,I~2=0%,OR=2.61,95%CI[1.72,3.98],and Z=4.49,P<0.01)was also improved compared with that in western medicine group(P=0.99,I~2=0%;OR=4.63,95%CI[2.04,10.01]);and the curative effect of Qufeng plus Western Medicine Group on cough variant asthma was also improved P=0.99,I~2=0%.The results of combined effect test were Z=3.67,P<0.01);compared with western medicine group,Qufeng method could significantly reduce the recurrence rate of cough variant asthma(heterogeneity test showed P=0.49,I~2=0%;OR=0.36,95%CI was[0.22,0.61]);the results of combined effect test were Z=3.86,P<0.01;compared with Western Medicine group,Qufeng method could significantly reduce the recurrence rate of cough variant asthma(heterogeneity test showed P=0.49,I~2=0%;OR=0.22,95%CI was[0.61]);the results of combined effect test were There was no significant difference between the control group(heterogeneity test(P<0.1,I~2=99%,SMD=3.20,95%CI[-0.13,6.52],Z=1.89,P=0.06).Compared with the western medicine group,there was no significant difference in the improvement of PEF between the treatment group and the control group(heterogeneity test P<0.1,I~2=93%.SMD=0.81,95%CI[-0.16,1.78],and Z=1.64,P=0.10)were calculated for the combined effect.Compared with the western medicine group,there was no significant difference in improving EOS between the treatment group and the control group(heterogeneity testP>0.1,I~2=31%,SMD=-0.11,95%CI[-0.30,0.08],Z=1.17,P=0.24).Conclusion According to the existing research,compared with western medicine treatment,Qufeng method can significantly improve the treatment efficiency and reduce the recurrence rate of cough variant asthma.However,due to the limited number of literatures,the low quality of methodology and the publication bias,the reliability of the conclusions will be affected.Therefore,multi-center,large-sample,high-quality randomized controlled trials are still needed to provide more high-quality evidence-based evidence for the treatment of cough variant asthma by Qufeng method and its combination of traditional Chinese and Western medicine.