Correlation Analysis Of P53Expression And Clinicopathological Parameters As Well As TCM Type In Breast Cancer

ObjectiveAnalyze the relations between p53expression and clinicopathological parameters aswell as TNM stage, age, menopausal status, TCM Type in120cases of breast cancer, toprovide objective indicators for the clinical and the prognosis of breast cancer.MethodsCollect192medical records of breast cancer from First Affiliated Hospital ofShandong University of Traditional Chinese Medicine. Filter out120appropriate copieswith complete pathologic and immunohistochemical from192medical records, whichwere from December2011to December2013. According to its pathologic andimmunohistochemical, use SPSS19.0to analyze the relations between expression of p53and pathological type, as well as histological grade, ER, PR, HER-2, Ki67, the type ofluminal, age, menopausal status, tumor size, the number of lymph nodes metastases,TNM stage, TCM Type. Use the chi-square test when analyze the relations betweenexpression of p53and unordered categorical variables; Use the spearman rank correlationanalysis when analyze the relations between expression of p53and ordered categoricalvariables, and calculate the correlation coefficientr. If the test result isp<α(α isthe significance level), the two variables have a significant correlation, otherwise, nosignificant correlation between the two variables. α is generally taken to be0.05or0.01.If it has a strong positive correlation between the two variables,rtends to be1. If it has anegative positive correlation between the two variables,rtends to be-1.rtends to be 0when it has a weak correlation between two variables.Results1. The expression of p53in120medical records:59copies were negative; the negativeexpression’s rate was49.2%;61copies were positive; the positive expression’s ratewas50.8%.2. The expression of p53was negatively correlated with the expression of ER(p=0.005<0.01,r=﹣0.254) and the expression of PR (p=0.002<0.01,r=﹣0.284).3. The expression of p53showed positively correlated with histological grade(p=0.002<0.01,r=0.276), as well as the expression of Her-2(p=0.018<0.05,r=0.216), the expression of Ki67(p=0.001<0.05,r=0.301), the number of lymphnodes metastases(p=0.015<0.05,r=0.221), TNM stage(p=0.021<0.05,r=0.211).4. The expression of p53was significantly correlated with the type of luminal(p=0.004<0.01).5. The expression of p53had no significant correlation with pathological type, age,menopausal status, tumor size and TCM Type.Conclusion1. In120breast cancer patients, p53positive rate is about50%-60%.2. The expression of p53is significantly associated with four independent prognosticindicators in breast cancer (ER, PR, Her-2, Ki67). Among it, p53expression isnegatively correlated with the expression of ER and PR, but is positively correlatedwith the expression of Her-2and Ki67. In addition, p53expression shows significantcorrelation with TNM type.3. The expression of p53would increase, if the expression of histological grade, themetastasis number of lymph node or TNM type increases.4. The expression of p53has no significant correlation with pathological type, age,menopausal status, tumor size and TCM Type.5. The expression of p53is a poor prognostic indicator, so its expression was negativelycorrelated with the prognosis. The research of p53will contribute to a more in-depthunderstanding of the biological behavior of breast cancer in combination with other prognostic factors. But whether p53can be as an independent prognostic factor stillneeds to be further explored.