Study On The Association Between Hyperhomocysteinemia And Cognitive Impairment In Parkinson’s Disease

Objective：To study factors affecting cognitive disorder of Parkinson’s sufferers; Tostudy the relationship between the level of homocysteine (Hcy) andcognitive disorder of old patients with Parkinson ’ s disease (PD); Toinvestigate the damaged condition of cognitive domain of Parkinson’ssufferers with cognitive disorder including visual space and executivefunction, memories, attentiveness, linguistic function, abstract thinkingability, directive force, naming ability etc which provides theoreticalfoundation for preventing and postponing PD sufferers’ cognitive disorder.Methods:To analyze retrospectively and compare the clinical data of50old patients(Parkinson’s disease group) who have Parkinson ’ s disease with30contemporaneous healthy cases (healthy control group); To apply unifiedMontreal Cognitive Assessment （MOCA） to PD patients to check theircognitive function; To test the level of plasma Hcy, folic acid, vitamin B12of people from Parkinson’s disease group and healthy control group; Toknow patients with cognitive disorder in the Parkinson’s disease groupabout age of onset, sick time, H&Y staging, initial symptom, level ofeducation, time and dosages of usage of Madopar, UA and other aspectsrelated to cognitive disorder of PD; To analyze the damaged condition of cognitive domain of Parkinson’s sufferers with cognitive disorder.Results:Results show that the level of plasma Hcy of patients in Parkinson’sdisease group is higher than research objects in healthy control groupwhile there is no statistical significance of comparative differencesbetween the two groups about the level of folic acid and vitamin B12. Thelevel of plasma Hcy of the patient group with PD cognitive disorder ishigher than research objects with normal cognitive state. It has beenfound that the occurrence of cognitive disorder is affected by H&Y stagingand level of education. There no significant correlation between thecognitive disorder and patients’ age of onset, sick time, initial symptom,time and dosages of usage of Madopar, UA and other aspects. It hasstatistical significance for PD cognitive disorder group about cognitiveimpairment happened in three cognitive domains including visual spaceand executive function, memories and abstract thinking ability while itshas no statistical significance in the cognitive domains includingattentiveness, linguistic function, directive force, naming ability, etc.compared with the group with normal cognitive state. In conclusion:Parkinson’s disease cognitive dysfunction plasma homocysteine level wassignificantly higher in patients with Parkinson’s disease and non-cognitivedysfunction group, suggesting that blood homocysteine levels andcognitive impairment in Parkinson’s disease and dementia.Conclusion:The author considers that there is relevance betweenhyperhomocysteinemia and Parkinson. It is regarded that the occurrenceof cognitive disorder of PD patients is affected by H&Y staging and level of education. Cognitive impairment is tend to appear in three cognitivedomains including visual space and executive function, memories andabstract thinking ability.