| Purpose:PD is also known as parkinsonism, and is a common degenerativedisease of the nervous system in middle-aged and elderly people. Themain clinical manifestations of the PD are static tremor, increasedmuscular tension, slow movement, abnormal posture and gait, and thelike.20%to40%of the people with the PD may have a declinedcognitive function; and in serious cases, dementia, namely, Parkinson’sdisease with dementia, PDD is appeared. Some studies have reported thatthe people with the PD have increased Hcy with long-term use of L-dopa;and some studies have shown that Hhcy is a risk factor of vasculardementia. This study aims to analyze the correlation between the Hhcyand the risk of PD cognition with impairment and dementia to provide abasis for PDD prevention.Method:Searching in PubMed from1951to2013, in CNKI from1997to2013, in Wanfang database from1980to2013, and in VIP from1980to2013to find out cohort studies and case control studies in the correlationbetween the Hcy and the PD with cognition impairment and dementiawith the searching time limit from database building to February,2014;adopting Review Manager5.2software to conduct Meta analysis on theliteratures matched with conditions.Result:Seven studies and people with the total number of1381are includedto analyze the relation between the Hhcy and the risk of the PD with cognition impairment and dementia. Controlled observation is conductedon an Hcy level and normal control group of the PD with cognitionimpairment and dementia with MD=8.08,95%CI[2.93~13.24], I2=97%,and a PD without dementia group with MD=-3.98,95%CI[-6.90~-0.87],and I2=86%, and the result shows that Hhcy is a risk factor for PD withcognition impairment and dementia.Conclusion:People with the PD cognition impairment and dementia have theHcy levels obviously higher than those of the control group and the PDwithout the dementia and cognition impairment group, so as to give a hintthat the Hcy level is related to the PD with cognition impairment anddementia. |
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