A Research Into The Correlation Between Type2Diabetes Mellitus And Liver Damage

Objective:To study the characteristics of patients who suffer from both Type2diabetes mellitus (T2DM) and liver damage, analyze the correlation factors of Type2diabetes and liver damage.Methods:According to common liver biochemistry experiment and the clinical significance of the evaluation by the Chinese medical association society of liver disease in2010. the T2DM patients was divided into two groups, including128cases of type2diabetes mellitus with liver damage and440cases of type2diabetes mellitus with non-liver damage. To measure the selected patients’ height, weight, and blood pressure, and calculate the BMI. Determine the fasting blood FBG, P2hBG, HbAlc, ALT, AST, GGT, ALP, and TBIL, blood fat, and renal function of the selected patients. Date analysis was done by the statistics software SPSS13.0with measurement data with mean+/-standard deviation (X+S) and the median (minimum and maximum), and the comparison between the two groups using t test and chi-square test, The normal distribution was used Pearson correlation analysis of two groups of data.Results:(1) In T2DM patients, compared with the non-liver damage, liver damage patients had higher lever of TG, HbAlc, FBG, P2hBG There ware statistically significant(p<0.05).(2) In T2DM patients, compared with the non-liver damage group, the liver damage group complicated with nephropathy (32.8%), neuropathy (21.2%), and retinopathy (12.5%), ketosis (16.4%), Nonketotic hyperosmolar state(6.3%) increased incidence of liver damage, There ware statistically significant(p<0.05). And concurrent big vascular lesions (19.5%) increased incidence of liver function damage, but there were not statistical significance (P>0.05).(3) In T2DM patients, compared with the non-liver damage group, the liver damage group with dyslipidemia (53.1%), nonalcoholic fatty liver disease (21.9%), cholelith disease (18.7%), and hepatitis b virus infection (15.6%), cholelith disease (18.7%), alcoholic fatty liver disease (12.5%), heavy drinking (11.7%) increased incidence of liver function damage, statistically significant (P <0.05). And with Clonorchiasis (6.3%) increased incidence of liver function damage, but there were no statistical significance (P<0.05). On the other hand With the virus infection by the hepatitis c (4.7%) when the liver damage rate had not obvious change.(3) The correlation analysis showed:there were positive correlation between ALT and TG, FBG, P2hBG (r=0.274, r=0.274, r=0.220, P<0.05); and AST was positively correlated with TG, P2hBG.(r=0.190, r=0.220, P<0.05).Conclusion:(1) A variety of reasons can lead to type2diabetes mellitus with liver damage, NAFLD was common.(2) High blood glucose and high triglycerides have positive correlation with type2diabetes when liver function damage.