The Influence Of Hypothyroxinmia On Pregnant Women And Infants

Objective Through detection of middle-late pregnancy pregnant women serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels, explore the incidence rate of pregnant women with hypothyroxinemia and the adverse impact of the pregnant women and infants and to timely detection and treatment of pregnant women with hypothyroxinemia provides the basis for women.The object of study We analyzed retrospectively141pregnant women with hypothyroxinemia who have maternity check and childbirth in the first affiliated hospital of guangxi medical university from January2013to October2013, the clinical data of pregnant women and their newborn as research group (with72people in treatment group and the treatment group is69people), and have58pregnant women that have maternity check and childbirth in our hospital as control group,who were randomly selected in the same period regular prenatal and no abnormal thyroid function and no other complication of childbirth.The research methods Through the determination the middle and late pregnant women’s free thyroxine (FT4) and thyroid stimulating hormone (TSH) level of the treatment group, the treatment group and normal group.To learn more about the late changes in thyroid function level (or differences) of the middle and late pregnant women. Statistical groups of pregnant women the incidence of complications and adverse pregnancy outcomes. To compare the general situation of the newborn and the free thyroxine (FT4) and thyroid-stimulating hormone (TSH) level of the newborn after72hours.Each birth usually and born after72hours of serum free thyroxine (FT4) and thyroid-stimulating hormone (TSH) level.Result①The change of the TSH and FT4on pregnant women:in the middle pregnancy:the treatment group and treatment group average of TSH were higher than in normal group, the difference was statistically significant (P<0.05).in the late pregnancy:the TSH level of no treatment group is significantly higher than the treatment group and normal group, the difference was statistically significant (P<0.05); The treatment group compared with normal control group there was no statistically significant difference (P>0.05).Middle and late pregnancy:the treatment group and the treatment group of FT4level is lower than normal group, the difference was statistically significant (P<0.05); And late pregnancy treatment group compared with no treatment group of FT4level, the difference was statistically significant (P<0.05).②Not the treatment group of pregnant women in late pregnancy for the development of the incidence of hypothyroidism pregnant women is significantly higher than the treatment group and normal group, the difference was statistically significant (P<0.05).Not the prevalence of gestational diabetes treatment group of pregnant women is significantly higher than the treatment group and normal group, the difference was statistically significant (P<0.05). Treatment group and not pregnant women’s pregnancy hypertension disease prevalence of treatment group was obviously higher than that of normal group, the difference was statistically significant (P<0.05).③The treatment group and treatment group of pregnant women delivery of neonatal weight low2500g rate is significantly higher than normal group, the difference was statistically significant (P<0.05). And to compare the treatment group, treatment group and normal group of pregnant women delivery of neonatal weight, average minute Apgar score rank and premature birth rate, there was no statistically significant difference (P>0.05).④Not treatment group of pregnant women neonatal JiaJian prevalence is significantly higher than the treatment group and normal group of neonatal JiaJian prevalence among pregnant women, and the difference was statistically significant (P<0.05).Treatment group and treatment group of pregnant women serum TSH level of the newborn group is significantly higher than normal pregnant women neonatal TSH level, the difference was statistically significant (P<0.05); But the treatment group and treatment group neonatal serum TSH level difference of pregnant women with no statistical significance (P>0.05).Comparing the treatment group, the treatment group and normal group of pregnant women of neonatal serum FT4level, there was no statistically significant difference (P>0.05).Conclusion1.The TSH levels of pregnant women with hypothyroxinemia significantly is decreased after treatment, which haveno difference with normal late pregnant women,it is showed that treatment is effective.2.pregnant women with hypothyroxinemia and gestational diabetes、low birth weight and other adverse pregnancy outcomes related have relationship. regnancy test and adjust the FT4levels is important or prenatal we and treatment is important to pregnant women with hypothyroxinemia in time.3.The newborn who give birth by Untreated group pregnant women was obviously higher got Hypothyroidism than that of the treatment group and normal group of neonatal newborn.4.The of TSH level of newborn who give birth by Untreated group pregnant women was obviously higher than that of the treatment group and normal group of neonatal newborn.5.The incidence of pregnant women with hypothyroxinemia is high and more easy develop in hypothyroidism.thyroid function and thyroid function screening monitoring during pregnancy timely detection and treatment of thyroid disease, to reduce the pregnant women of pregnancy complications, complications, and the occurrence of adverse outcomes of pregnant women and newborn has important significance.