The Analysis Of Clinical Hypothyroidism With Complications And Adverse Outcome During Pregnancy

Objective: To explore the relationship between clinical hypothyroidism during pregnancy,pregnancy complications and adverse pregnancy outcomes by comparing clinical pregnancy complications and delivery outcomes.Methods: Collected from January 2016 to December 2017 at the First Affiliated Hospital of Guangxi Medical University,109 maternal who with clinical hypothyroidism during pregnancy were selected as case group.Another 115 maternal with normal pregnant as the control group.Both data ware completed.Ensure the two group’s related data during pregnancy is completed.A retrospective analysis of the age,gestational age,days of pregnancy,body mass index,three items of thyroid function(TSH,FT3,FT4),blood glucose(fasting blood glucose,1 hours postprandial blood glucose,2 hours postprandial blood glucose),urine protein,blood pressure,hemoglobin,caesarean section,postpartum hemorrhage,premature rupture of membrane,intrahepatic cholestasis,placental abnormality(placental abruption,placenta incarceration,placenta adherence,placenta previa),preterm birth,neonatal weight,fetal distress,neonatal malformation,neonatal asphyxia and so on.The methods of statistical processing were mainly independent sample t test,nonparametric test,Pearson chi square test and Fisher exact probability method.Results: There was no significant difference in the general data between the clinical hypothyroidism group and the control group,such as age,gestational age and BMI(P>0.05).The incidence of gestational diabetes mellitus,hypertensive disorder complicating pregnancy and anemia during pregnancy were higher than those in normal group,and the difference was statistically significant(P<0.05).The incidence of caesarean section,abnormal placenta,preterm labor and fetal malformation in the clinical hypothyroidism group was higher than that of the normal group(P<0.05).There was no significant difference in the incidence of postpartum hemorrhage,intrahepatic cholestasis,premature rupture of membranes and low weight infants between the two groups(P>0.05).There was a statistically significant difference in postprandial 2 hours blood glucose between pregnant hypothyroidism group and normal group(P<0.05),and there was no significant difference in fasting blood glucose and postprandial 1 hour blood glucose(P>0.05).Conclusions: Gestational diabetes,gestational hypertension,anemia and other complications,including cesarean section,placental abnormality,premature delivery,fetal malformation and other adverse pregnancy outcomes,were higher than those in normal group.The incidence of gestational diabetes in the clinical hypothyroidism group was higher than that in the control group,and the blood glucose increased obviously at 2 hours after the meal.