Study On The Correlation Between Isolated Hypothyroidemia And Pregnancy Outcome In The Third Trimester

Objective The adverse effect of untreatment isolated hypothyroxinemia in late pregnancy on pregnancy outcome was analyzed retrospectively.Methods A total of 107 women with simple hypothyroidism in the third trimester who gave birth in obstetrics department of our hospital were selected as the case group and 105 women with normal thyroid function during pregnancy as the control group.The case group was divided into group A(less than 10%,n=62)and group B(5% ~ 10%,n=45)according to the degree below the normal reference range of our hospital.The basic data,thyroid function,glucose tolerance test results,pregnancy complications and pregnancy outcomes of each group were compared.Results The age and pre-pregnancy BMI of the pregnant women in group A and group B were significantly higher than those in the thyroxine normal group(P < 0.05).The gestation weeks of thyroid function in the third trimester of pregnancy in group B were smaller than that in the normal group and group A,with statistically significant difference(P < 0.05).There was no significant difference in 2h blood glucose between group A and group B,but it was significantly higher than that of the control group(P < 0.05).FT4 content in both groups was significantly lower than that of the control group,and there was also A significant difference in FT4 content between the two groups(P < 0.001).The difference between prenatal BMI and pre-pregnancy BMI of group A was significantly higher than that of group B and control group(P < 0.05),and the difference was statistically significant.The incidence of PROM in group A and group B was significantly higher than that in the control group(P < 0.05),but there was nosignificant difference between the two groups.The incidence of dystocia midwifery in group A was significantly higher than that in control group and group B(P < 0.05),and there was no significant difference in the incidence of dystocia midwifery between group B and control group.Neonatal birth weight in group A was significantly higher than that in group B(P < 0.05),and there was no significant difference between the normal group and group B.The gestational age of group B was significantly lower than that of group A and control group(P < 0.05),and there was no difference between the normal group and group A.There was no significant difference in other indexes(P >.05).There was a negative correlation between FT4 and maternal age,pre-pregnancy BMI,2h blood glucose value,newborn birth weight and the difference between prenatal BMI and pre-pregnancy BMI,with statistically significant differences(P < 0.05),but the correlation was not significant.Conclusion The higher a woman's age and weight,the greater the risk of developing simple hypothyroidism in late pregnancy.Elevated blood glucose at 2h during glucose tolerance screening during pregnancy may increase the incidence of hypothyroxinemia later in life.In the third trimester,IH may increase the incidence of premature rupture of membranes and obstructed midwifery,and may increase the birth weight and gestational age of newborns.There was no significant correlation between FT4 and relevant indicators.